Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms
We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing on high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic spasms (TS) and then identified factors associated with corpus callosotomy (CC) outcomes. We enrolled 17 patients wi...
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| Veröffentlicht in: | Scientific reports 2019-12, Vol.9 (1), p.19733-7, Article 19733 |
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| creator | Kanai, Sotaro Oguri, Masayoshi Okanishi, Tohru Itamura, Shinji Baba, Shimpei Nishimura, Mitsuyo Homma, Yoichiro Maegaki, Yoshihiro Enoki, Hideo Fujimoto, Ayataka |
| description | We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing on high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic spasms (TS) and then identified factors associated with corpus callosotomy (CC) outcomes. We enrolled 17 patients with ES/TS who underwent CC before 20 years of age. Post-CC Engel’s classification was as follows: I in 7 patients, II in 2, III in 4, and IV in 4. Welch’s t-test was used to analyse the correlation between ictal HVSs and CC outcomes based on the following three symmetrical indices: (1) negative peak delay: interhemispheric delay between negative peaks; (2) amplitude ratio: interhemispheric ratio of amplitude values for the highest positive peaks; and (3) duration ratio: interhemispheric ratio of slow wave duration. Ages at CC ranged from 17–237 months. Four to 15 ictal EEGs were analysed for each patient. The negative peak delay, amplitude ratio and duration ratio ranged from 0–530 ms, 1.00–7.40 and 1.00–2.74, respectively. The negative peak delay, amplitude ratio and duration ratio were significantly higher in the seizure residual group (
p
= 0.017, |
| doi_str_mv | 10.1038/s41598-019-56303-3 |
| format | Article |
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p
= 0.017, <0.001, <0.001, respectively). Symmetry of ictal HVSs may predict favourable outcomes following CC for ES/TS.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-56303-3</identifier><identifier>PMID: 31875025</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/1689/178 ; 692/617/375/178 ; Adolescent ; Adult ; Brain Waves ; Cerebral hemispheres ; Child ; Child, Preschool ; Corpus callosum ; Corpus Callosum - physiopathology ; Corpus Callosum - surgery ; EEG ; Epilepsy ; Female ; Humanities and Social Sciences ; Humans ; Infant ; Infant, Newborn ; Male ; multidisciplinary ; Science ; Science (multidisciplinary) ; Spasms, Infantile - physiopathology ; Spasms, Infantile - surgery ; Symmetry</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.19733-7, Article 19733</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-1bf1b640c40802c82ec343a57f5ffb05f98146982e9eeb904c767d69cbd2e3663</citedby><cites>FETCH-LOGICAL-c540t-1bf1b640c40802c82ec343a57f5ffb05f98146982e9eeb904c767d69cbd2e3663</cites><orcidid>0000-0002-7320-2346 ; 0000-0003-3295-2236</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31875025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanai, Sotaro</creatorcontrib><creatorcontrib>Oguri, Masayoshi</creatorcontrib><creatorcontrib>Okanishi, Tohru</creatorcontrib><creatorcontrib>Itamura, Shinji</creatorcontrib><creatorcontrib>Baba, Shimpei</creatorcontrib><creatorcontrib>Nishimura, Mitsuyo</creatorcontrib><creatorcontrib>Homma, Yoichiro</creatorcontrib><creatorcontrib>Maegaki, Yoshihiro</creatorcontrib><creatorcontrib>Enoki, Hideo</creatorcontrib><creatorcontrib>Fujimoto, Ayataka</creatorcontrib><title>Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing on high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic spasms (TS) and then identified factors associated with corpus callosotomy (CC) outcomes. We enrolled 17 patients with ES/TS who underwent CC before 20 years of age. Post-CC Engel’s classification was as follows: I in 7 patients, II in 2, III in 4, and IV in 4. Welch’s t-test was used to analyse the correlation between ictal HVSs and CC outcomes based on the following three symmetrical indices: (1) negative peak delay: interhemispheric delay between negative peaks; (2) amplitude ratio: interhemispheric ratio of amplitude values for the highest positive peaks; and (3) duration ratio: interhemispheric ratio of slow wave duration. Ages at CC ranged from 17–237 months. Four to 15 ictal EEGs were analysed for each patient. The negative peak delay, amplitude ratio and duration ratio ranged from 0–530 ms, 1.00–7.40 and 1.00–2.74, respectively. The negative peak delay, amplitude ratio and duration ratio were significantly higher in the seizure residual group (
p
= 0.017, <0.001, <0.001, respectively). 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanai, Sotaro</au><au>Oguri, Masayoshi</au><au>Okanishi, Tohru</au><au>Itamura, Shinji</au><au>Baba, Shimpei</au><au>Nishimura, Mitsuyo</au><au>Homma, Yoichiro</au><au>Maegaki, Yoshihiro</au><au>Enoki, Hideo</au><au>Fujimoto, Ayataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-24</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>19733</spage><epage>7</epage><pages>19733-7</pages><artnum>19733</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing on high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic spasms (TS) and then identified factors associated with corpus callosotomy (CC) outcomes. We enrolled 17 patients with ES/TS who underwent CC before 20 years of age. Post-CC Engel’s classification was as follows: I in 7 patients, II in 2, III in 4, and IV in 4. Welch’s t-test was used to analyse the correlation between ictal HVSs and CC outcomes based on the following three symmetrical indices: (1) negative peak delay: interhemispheric delay between negative peaks; (2) amplitude ratio: interhemispheric ratio of amplitude values for the highest positive peaks; and (3) duration ratio: interhemispheric ratio of slow wave duration. Ages at CC ranged from 17–237 months. Four to 15 ictal EEGs were analysed for each patient. The negative peak delay, amplitude ratio and duration ratio ranged from 0–530 ms, 1.00–7.40 and 1.00–2.74, respectively. The negative peak delay, amplitude ratio and duration ratio were significantly higher in the seizure residual group (
p
= 0.017, <0.001, <0.001, respectively). Symmetry of ictal HVSs may predict favourable outcomes following CC for ES/TS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31875025</pmid><doi>10.1038/s41598-019-56303-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7320-2346</orcidid><orcidid>https://orcid.org/0000-0003-3295-2236</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/1689/178 692/617/375/178 Adolescent Adult Brain Waves Cerebral hemispheres Child Child, Preschool Corpus callosum Corpus Callosum - physiopathology Corpus Callosum - surgery EEG Epilepsy Female Humanities and Social Sciences Humans Infant Infant, Newborn Male multidisciplinary Science Science (multidisciplinary) Spasms, Infantile - physiopathology Spasms, Infantile - surgery Symmetry |
| title | Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms |
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