Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination

Multidrug resistant organisms are a serious threat to human health 1 , 2 . Fast, accurate antibiotic susceptibility testing (AST) is a critical need in addressing escalating antibiotic resistance, since delays in identifying multidrug resistant organisms increase mortality 3 , 4 and use of broad-spe...

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Veröffentlicht in:	Nature medicine 2019-12, Vol.25 (12), p.1858-1864
Hauptverfasser:	Bhattacharyya, Roby P., Bandyopadhyay, Nirmalya, Ma, Peijun, Son, Sophie S., Liu, Jamin, He, Lorrie L., Wu, Lidan, Khafizov, Rustem, Boykin, Rich, Cerqueira, Gustavo C., Pironti, Alejandro, Rudy, Robert F., Patel, Milesh M., Yang, Rui, Skerry, Jennifer, Nazarian, Elizabeth, Musser, Kimberly A., Taylor, Jill, Pierce, Virginia M., Earl, Ashlee M., Cosimi, Lisa A., Shoresh, Noam, Beechem, Joseph, Livny, Jonathan, Hung, Deborah T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/107 631/326/2521 631/326/41/2532 692/699/255/1318 Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Assaying Biomedical and Life Sciences Biomedicine Cancer Research Change detection Coupling (molecular) Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial - genetics Epidemiology Genetic analysis Genetic aspects Genotype Genotypes Health aspects Humans Hybridization Infectious Diseases Learning algorithms Letter Machine Learning Metabolic Diseases Microbial Sensitivity Tests Molecular Medicine Multidrug resistance Multidrug resistant organisms Neurosciences Organisms Phenotype Phenotypes Ribonucleic acid RNA RNA, Bacterial - drug effects RNA, Bacterial - isolation & purification Simultaneous discrimination learning Testing Transcription
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