T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells

Although viral infections elicit robust interferon-γ (IFN-γ) and long-lived antibody-secreting cell (ASC) responses, the roles for IFN-γ and IFN-γ-induced transcription factors (TFs) in ASC development are unclear. We showed that B cell intrinsic expression of IFN-γR and the IFN-γ-induced TF T-bet w...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-05, Vol.50 (5), p.1172-1187.e7
Hauptverfasser:	Stone, Sara L., Peel, Jessica N., Scharer, Christopher D., Risley, Christopher A., Chisolm, Danielle A., Schultz, Michael D., Yu, Bingfei, Ballesteros-Tato, André, Wojciechowski, Wojciech, Mousseau, Betty, Misra, Ravi S., Hanidu, Adedayo, Jiang, Huiping, Qi, Zhenhao, Boss, Jeremy M., Randall, Troy D., Brodeur, Scott R., Goldrath, Ananda W., Weinmann, Amy S., Rosenberg, Alexander F., Lund, Frances E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody-Producing Cells - immunology antibody-secreting cells B cell differentiation B-Lymphocytes - cytology B-Lymphocytes - immunology Binding sites Cell differentiation Cell Differentiation - immunology Cells, Cultured Chromatin Chromatin - metabolism Datasets Differentiation (biology) Effector cells Experiments Gene expression IFN-γ Infections Inflammation Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Interferon Interferon gamma Receptor Interferon-gamma - immunology Interleukin 4 Lymphocytes B Mice Mice, Inbred C57BL Mice, Knockout Nematospiroides dubius - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Positive Regulatory Domain I-Binding Factor 1 - biosynthesis Receptors, Interferon - metabolism Strongylida Infections - immunology Strongylida Infections - parasitology T-bet T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Helper-Inducer - immunology Transcription factors γ-Interferon
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