A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling

Granzyme B (GrB) is an essential cytotoxic effector in cancer immunotherapy as it can be a potential biomarker to predict the efficacy of immunotherapies including checkpoint inhibitors. Monitoring the Granzyme B activity in cells would help determine a patient's clinical response to treatment...

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Veröffentlicht in:	Theranostics 2020, Vol.10 (1), p.123-132
Hauptverfasser:	Briones, Jonathan C, Espulgar, Wilfred V, Koyama, Shohei, Yoshikawa, Hiroyuki, Park, JeongHoon, Naito, Yujiro, Kumanogoh, Atsushi, Tamiya, Eiichi, Takamatsu, Hyota, Saito, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Cytotoxicity Enzymes Granzymes - metabolism Humans Jurkat Cells Leukocytes, Mononuclear - enzymology Lung Neoplasms - drug therapy Lymphocytes Microfluidics - instrumentation Microfluidics - methods Peptides Research Paper Silicon wafers Single-Cell Analysis - instrumentation Single-Cell Analysis - methods THP-1 Cells
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