From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells

Electrical activity in neurons and other excitable cells is a result of complex interactions between the system of ion channels, involving both global coupling (e.g., via voltage or bulk cytosolic Ca concentration) of the channels, and local coupling in ion channel complexes (e.g., via local Ca conc...

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Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (23), p.6057
Hauptverfasser:	Montefusco, Francesco, Pedersen, Morten G
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Approximation Bursting Calcium - metabolism Calcium channels Calcium channels (voltage-gated) Calcium Channels - metabolism Calcium influx Calcium ions Calcium signalling Computer Simulation Cytoplasmic Granules - chemistry Cytoplasmic Granules - metabolism Exocytosis Exocytosis - physiology Firing pattern Granular materials Hormones Humans Ion Channel Gating - physiology Ion channels Kinetics Large-Conductance Calcium-Activated Potassium Channels - metabolism Models, Biological Normalizing Pituitary Pituitary Gland - cytology Pituitary Gland - metabolism Potassium conductance Potassium currents Probability Proteins Resistance Somatotrophs - cytology Somatotrophs - metabolism Stoichiometry
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