Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a n...
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| Veröffentlicht in: | International journal of molecular sciences 2019-11, Vol.20 (23), p.5889 |
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| creator | Matica, Mariana Adina Aachmann, Finn Lillelund Tøndervik, Anne Sletta, Håvard Ostafe, Vasile |
| description | Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market. |
| doi_str_mv | 10.3390/ijms20235889 |
| format | Article |
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Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. 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| ispartof | International journal of molecular sciences, 2019-11, Vol.20 (23), p.5889 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Acids Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteria Bacteria - drug effects Bandages Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biodegradability Biofilms Biopolymers By products Cell Wall - drug effects Chitosan Chitosan - chemistry Chitosan - metabolism Chitosan - pharmacology Crustaceans DNA, Bacterial - metabolism Drug resistance Fungi - drug effects Gram-positive bacteria Hydrogen-Ion Concentration Infections Mammalian cells Medical dressings Microorganisms Molecular weight Natural polymers Pathogens Polymers Reagents Review Seafood Wound healing Wound Healing - drug effects |
| title | Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action |
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