Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function?

Epithelial/endothelial cells adhere to each other via cell-cell junctions including tight junctions (TJs) and adherens junctions (AJs). TJs and AJs are spatiotemporally and functionally integrated, and are thus often collectively defined as apical junctional complexes (AJCs), regulating a number of...

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Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (23), p.6012
Hauptverfasser:	Tsukita, Kazuto, Yano, Tomoki, Tamura, Atsushi, Tsukita, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate Adenosine triphosphate Adherens junctions Adherens Junctions - metabolism AMP-Activated Protein Kinases - metabolism Animals Cell junctions Cell Polarity Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Energy Metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Experiments Humans Insects Intracellular signalling Kinases LKB1 protein Localization Metabolism Molecular modelling Morphogenesis Mutation Permeability Phosphatase Phosphorylation Polarity Protein kinase Proteins Review Signal Transduction Therapeutic targets Tight junctions Tight Junctions - metabolism Transcription factors
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