Simplified Head-to-Tail Cyclic Polypeptides as Biomaterial-Associated Antimicrobials with Endotoxin Neutralizing and Anti-Inflammatory Capabilities

The therapeutic application of antimicrobial peptides (AMPs), a potential type of peptide-based biomaterial, is impeded by their poor antimicrobial activity and potential cytotoxicity as a lack of understanding of their structure-activity relationships. In order to comprehensively enhance the antiba...

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Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (23), p.5904
Hauptverfasser:	Dong, Na, Wang, Chensi, Li, Xinran, Guo, Yuming, Li, Xiaoli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - toxicity Amino acids Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antibiotics Antimicrobial activity Antimicrobial agents Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Aqueous solutions Bacteria Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomaterials Biomedical materials Cell Death Cytotoxicity Dermatitis Dermatitis - drug therapy Dermatitis - etiology Dermatitis - pathology Design Drug resistance Electron microscopy Endotoxins Endotoxins - pharmacology Fluorescence Gene expression Gram-negative bacteria Gram-positive bacteria Gramicidin Hemolysis - drug effects Humans IL-1β Inflammation Interleukin 6 Lipopolysaccharides Lipopolysaccharides - pharmacology Lysis Male Membranes Mice Mice, Inbred ICR Molecular weight Oxazolone - toxicity Peptides Peptides - chemistry Peptides - pharmacology Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Polypeptides Proline RAW 264.7 Cells Selectivity Staphylococcus infections Surface plasmon resonance Tails Tumor necrosis factor-α
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