Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis

Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. Objective: To identify cognitive functions associated with anxiety and depression in MS...

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Veröffentlicht in:Multiple sclerosis 2020-09, Vol.26 (10), p.1247-1255
Hauptverfasser: Leavitt, Victoria M, Brandstadter, Rachel, Fabian, Michelle, Katz Sand, Ilana, Klineova, Sylvia, Krieger, Stephen, Lewis, Christina, Lublin, Fred, Miller, Aaron, Pelle, Gabrielle, Buyukturkoglu, Korhan, De Jager, Phillip L, Li, Peipei, Riley, Claire S, Tsapanou, Angeliki, Sumowski, James F
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container_end_page 1255
container_issue 10
container_start_page 1247
container_title Multiple sclerosis
container_volume 26
creator Leavitt, Victoria M
Brandstadter, Rachel
Fabian, Michelle
Katz Sand, Ilana
Klineova, Sylvia
Krieger, Stephen
Lewis, Christina
Lublin, Fred
Miller, Aaron
Pelle, Gabrielle
Buyukturkoglu, Korhan
De Jager, Phillip L
Li, Peipei
Riley, Claire S
Tsapanou, Angeliki
Sumowski, James F
description Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. Objective: To identify cognitive functions associated with anxiety and depression in MS. Methods: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. Results: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = –0.220, p = 0.003) and lower depression to better attention/processing speed (rp = –0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = –0.271, p = 0.028) and lower depression to better attention/processing speed (rp = –0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. Conclusion: Consistent mood–cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
doi_str_mv 10.1177/1352458519860319
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Objective: To identify cognitive functions associated with anxiety and depression in MS. Methods: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. Results: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = –0.220, p = 0.003) and lower depression to better attention/processing speed (rp = –0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = –0.271, p = 0.028) and lower depression to better attention/processing speed (rp = –0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. Conclusion: Consistent mood–cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458519860319</identifier><identifier>PMID: 31233379</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anxiety ; Cognition &amp; reasoning ; Cognitive ability ; Intelligence ; Memory ; Mental depression ; Mood ; Multiple sclerosis</subject><ispartof>Multiple sclerosis, 2020-09, Vol.26 (10), p.1247-1255</ispartof><rights>The Author(s), 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-264e2574f851a09a27183e6a52aea5fd7a25eb608245eed43b094476786818b3</citedby><cites>FETCH-LOGICAL-c462t-264e2574f851a09a27183e6a52aea5fd7a25eb608245eed43b094476786818b3</cites><orcidid>0000-0002-0406-0460 ; 0000-0001-6111-4907 ; 0000-0002-2298-1589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1352458519860319$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1352458519860319$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,777,781,882,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31233379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leavitt, Victoria M</creatorcontrib><creatorcontrib>Brandstadter, Rachel</creatorcontrib><creatorcontrib>Fabian, Michelle</creatorcontrib><creatorcontrib>Katz Sand, Ilana</creatorcontrib><creatorcontrib>Klineova, Sylvia</creatorcontrib><creatorcontrib>Krieger, Stephen</creatorcontrib><creatorcontrib>Lewis, Christina</creatorcontrib><creatorcontrib>Lublin, Fred</creatorcontrib><creatorcontrib>Miller, Aaron</creatorcontrib><creatorcontrib>Pelle, Gabrielle</creatorcontrib><creatorcontrib>Buyukturkoglu, Korhan</creatorcontrib><creatorcontrib>De Jager, Phillip L</creatorcontrib><creatorcontrib>Li, Peipei</creatorcontrib><creatorcontrib>Riley, Claire S</creatorcontrib><creatorcontrib>Tsapanou, Angeliki</creatorcontrib><creatorcontrib>Sumowski, James F</creatorcontrib><title>Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. Objective: To identify cognitive functions associated with anxiety and depression in MS. Methods: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. Results: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = –0.220, p = 0.003) and lower depression to better attention/processing speed (rp = –0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = –0.271, p = 0.028) and lower depression to better attention/processing speed (rp = –0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. Conclusion: Consistent mood–cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. 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Brandstadter, Rachel ; Fabian, Michelle ; Katz Sand, Ilana ; Klineova, Sylvia ; Krieger, Stephen ; Lewis, Christina ; Lublin, Fred ; Miller, Aaron ; Pelle, Gabrielle ; Buyukturkoglu, Korhan ; De Jager, Phillip L ; Li, Peipei ; Riley, Claire S ; Tsapanou, Angeliki ; Sumowski, James F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-264e2574f851a09a27183e6a52aea5fd7a25eb608245eed43b094476786818b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anxiety</topic><topic>Cognition &amp; reasoning</topic><topic>Cognitive ability</topic><topic>Intelligence</topic><topic>Memory</topic><topic>Mental depression</topic><topic>Mood</topic><topic>Multiple sclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leavitt, Victoria M</creatorcontrib><creatorcontrib>Brandstadter, Rachel</creatorcontrib><creatorcontrib>Fabian, Michelle</creatorcontrib><creatorcontrib>Katz Sand, Ilana</creatorcontrib><creatorcontrib>Klineova, Sylvia</creatorcontrib><creatorcontrib>Krieger, Stephen</creatorcontrib><creatorcontrib>Lewis, Christina</creatorcontrib><creatorcontrib>Lublin, Fred</creatorcontrib><creatorcontrib>Miller, Aaron</creatorcontrib><creatorcontrib>Pelle, Gabrielle</creatorcontrib><creatorcontrib>Buyukturkoglu, Korhan</creatorcontrib><creatorcontrib>De Jager, Phillip L</creatorcontrib><creatorcontrib>Li, Peipei</creatorcontrib><creatorcontrib>Riley, Claire S</creatorcontrib><creatorcontrib>Tsapanou, Angeliki</creatorcontrib><creatorcontrib>Sumowski, James F</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leavitt, Victoria M</au><au>Brandstadter, Rachel</au><au>Fabian, Michelle</au><au>Katz Sand, Ilana</au><au>Klineova, Sylvia</au><au>Krieger, Stephen</au><au>Lewis, Christina</au><au>Lublin, Fred</au><au>Miller, Aaron</au><au>Pelle, Gabrielle</au><au>Buyukturkoglu, Korhan</au><au>De Jager, Phillip L</au><au>Li, Peipei</au><au>Riley, Claire S</au><au>Tsapanou, Angeliki</au><au>Sumowski, James F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>26</volume><issue>10</issue><spage>1247</spage><epage>1255</epage><pages>1247-1255</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><abstract>Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. 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source SAGE Complete A-Z List
subjects Anxiety
Cognition & reasoning
Cognitive ability
Intelligence
Memory
Mental depression
Mood
Multiple sclerosis
title Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis
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