Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine
Oxidative stress plays a crucial role in the development of diseases induced by welding fumes. To our knowledge, little information is available on the relationship between multiple heavy metal exposure and oxidative stress in welders. We assessed the relationship between multiple heavy metal exposu...
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| Veröffentlicht in: | International journal of environmental research and public health 2019-11, Vol.16 (23), p.4813 |
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| description | Oxidative stress plays a crucial role in the development of diseases induced by welding fumes. To our knowledge, little information is available on the relationship between multiple heavy metal exposure and oxidative stress in welders. We assessed the relationship between multiple heavy metal exposure and oxidative damage by analyzing 174 nonsmoking male welders in a shipyard. Urinary metals were used as the internal dose of exposure to metals in welding fumes, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers' metal levels and 8-OHdG was estimated using a multiple linear regression model. The geometric mean levels of urinary chromium (Cr), nickel (Ni), cadmium (Cd), and lead (Pb) were considerably higher in welders than in controls. Urinary Cr and Ni were determined as effective predictors of urinary 8-OHdG levels after adjusting for covariates. Oxidative DNA damage was associated with both Cr and Ni of welding fume exposure in shipyard welders (Ln Cr: β = 0.33, 95%C.I. = 0.16-0.49; Ln Ni: β = 0.27, 95%C.I. = 0.12-0.43). In this study, we investigated the significantly positive relationship between urinary metals (especially Cr and Ni) and 8-OHdG in nonsmoking shipyard welders. Moreover, the use of particulate respirators did not reduce metal exposure and oxidative damage. Therefore, we infer that hazard identification for welders should be conducted. |
| doi_str_mv | 10.3390/ijerph16234813 |
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To our knowledge, little information is available on the relationship between multiple heavy metal exposure and oxidative stress in welders. We assessed the relationship between multiple heavy metal exposure and oxidative damage by analyzing 174 nonsmoking male welders in a shipyard. Urinary metals were used as the internal dose of exposure to metals in welding fumes, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers' metal levels and 8-OHdG was estimated using a multiple linear regression model. The geometric mean levels of urinary chromium (Cr), nickel (Ni), cadmium (Cd), and lead (Pb) were considerably higher in welders than in controls. Urinary Cr and Ni were determined as effective predictors of urinary 8-OHdG levels after adjusting for covariates. Oxidative DNA damage was associated with both Cr and Ni of welding fume exposure in shipyard welders (Ln Cr: β = 0.33, 95%C.I. = 0.16-0.49; Ln Ni: β = 0.27, 95%C.I. = 0.12-0.43). In this study, we investigated the significantly positive relationship between urinary metals (especially Cr and Ni) and 8-OHdG in nonsmoking shipyard welders. Moreover, the use of particulate respirators did not reduce metal exposure and oxidative damage. Therefore, we infer that hazard identification for welders should be conducted.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16234813</identifier><identifier>PMID: 31795521</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>8-Hydroxy-2'-Deoxyguanosine - analysis ; Age ; Air Pollutants, Occupational - analysis ; Air Pollutants, Occupational - toxicity ; Biomarkers ; Biomarkers - urine ; Biomonitoring ; Cigarette smoking ; Creatinine ; Deoxyguanosine ; Deoxyribonucleic acid ; DNA ; DNA Damage ; Exposure ; Fumes ; Heavy metals ; Humans ; Linear Models ; Lung cancer ; Male ; Mass spectrometry ; Metal workers ; Metals, Heavy - analysis ; Metals, Heavy - toxicity ; Middle Aged ; Occupational exposure ; Occupational Exposure - analysis ; Organic chemistry ; Oxidative Stress ; Questionnaires ; Regression analysis ; Scientific imaging ; Shipyards ; Smoking ; Sociodemographics ; Statistical analysis ; Statistical methods ; Urine ; Welding ; Welding machines</subject><ispartof>International journal of environmental research and public health, 2019-11, Vol.16 (23), p.4813</ispartof><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-89c60d8be53971f8583af5f729aed336499758630edf89ac5718df03f5f246553</citedby><cites>FETCH-LOGICAL-c348t-89c60d8be53971f8583af5f729aed336499758630edf89ac5718df03f5f246553</cites><orcidid>0000-0001-5097-8574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926754/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926754/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31795521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Ting-Yao</creatorcontrib><creatorcontrib>Pan, Chih-Hong</creatorcontrib><creatorcontrib>Hsu, Yuan-Ting</creatorcontrib><creatorcontrib>Lai, Ching-Huang</creatorcontrib><title>Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Oxidative stress plays a crucial role in the development of diseases induced by welding fumes. To our knowledge, little information is available on the relationship between multiple heavy metal exposure and oxidative stress in welders. We assessed the relationship between multiple heavy metal exposure and oxidative damage by analyzing 174 nonsmoking male welders in a shipyard. Urinary metals were used as the internal dose of exposure to metals in welding fumes, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers' metal levels and 8-OHdG was estimated using a multiple linear regression model. The geometric mean levels of urinary chromium (Cr), nickel (Ni), cadmium (Cd), and lead (Pb) were considerably higher in welders than in controls. Urinary Cr and Ni were determined as effective predictors of urinary 8-OHdG levels after adjusting for covariates. Oxidative DNA damage was associated with both Cr and Ni of welding fume exposure in shipyard welders (Ln Cr: β = 0.33, 95%C.I. = 0.16-0.49; Ln Ni: β = 0.27, 95%C.I. = 0.12-0.43). In this study, we investigated the significantly positive relationship between urinary metals (especially Cr and Ni) and 8-OHdG in nonsmoking shipyard welders. Moreover, the use of particulate respirators did not reduce metal exposure and oxidative damage. Therefore, we infer that hazard identification for welders should be conducted.</description><subject>8-Hydroxy-2'-Deoxyguanosine - analysis</subject><subject>Age</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Air Pollutants, Occupational - toxicity</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Biomonitoring</subject><subject>Cigarette smoking</subject><subject>Creatinine</subject><subject>Deoxyguanosine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Exposure</subject><subject>Fumes</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Metal workers</subject><subject>Metals, Heavy - analysis</subject><subject>Metals, Heavy - toxicity</subject><subject>Middle Aged</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Organic chemistry</subject><subject>Oxidative Stress</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Scientific imaging</subject><subject>Shipyards</subject><subject>Smoking</subject><subject>Sociodemographics</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Urine</subject><subject>Welding</subject><subject>Welding machines</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkUtPwzAQhC0EoryuHJElDpxS_IgdmwNSVQpF4nEAxNEyyZqmauNgJ1Xz7wkqIDjtSDs7-0mD0DElQ841OS_nEOoZlYynivIttEelJEkqCd3-owdoP8Y5IVylUu-iAaeZFoLRPeQmzkHeROwdnoJddfgeGrvAk3XtYxsA-wo_zcq6s6HAr7AoIMQLPMJj2zalr2zo8INvADsfsEqmXRH8ukvYWXIFvXhvbeVjWcEh2nF2EeHoex6gl-vJ83ia3D3e3I5Hd0ne8zeJ0rkkhXoDwXVGnRKKWydcxrSFgnOZap0JJTmBwiltc5FRVTjCew9LpRD8AF1ucuv2bQlFDlUT7MLUoVz2qMbb0vzfVOXMvPuVkZrJTKR9wOl3QPAfLcTGzH0bqp7ZMM600EJy1ruGG1cefIwB3O8HSsxXL-Z_L_3ByV-uX_tPEfwTvDuKRg</recordid><startdate>20191129</startdate><enddate>20191129</enddate><creator>Su, Ting-Yao</creator><creator>Pan, Chih-Hong</creator><creator>Hsu, Yuan-Ting</creator><creator>Lai, Ching-Huang</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5097-8574</orcidid></search><sort><creationdate>20191129</creationdate><title>Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine</title><author>Su, Ting-Yao ; Pan, Chih-Hong ; Hsu, Yuan-Ting ; Lai, Ching-Huang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-89c60d8be53971f8583af5f729aed336499758630edf89ac5718df03f5f246553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>8-Hydroxy-2'-Deoxyguanosine - analysis</topic><topic>Age</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Air Pollutants, Occupational - toxicity</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>Biomonitoring</topic><topic>Cigarette smoking</topic><topic>Creatinine</topic><topic>Deoxyguanosine</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Exposure</topic><topic>Fumes</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Metal workers</topic><topic>Metals, Heavy - analysis</topic><topic>Metals, Heavy - toxicity</topic><topic>Middle Aged</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Organic chemistry</topic><topic>Oxidative Stress</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Scientific imaging</topic><topic>Shipyards</topic><topic>Smoking</topic><topic>Sociodemographics</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Urine</topic><topic>Welding</topic><topic>Welding machines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Ting-Yao</creatorcontrib><creatorcontrib>Pan, Chih-Hong</creatorcontrib><creatorcontrib>Hsu, Yuan-Ting</creatorcontrib><creatorcontrib>Lai, Ching-Huang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Ting-Yao</au><au>Pan, Chih-Hong</au><au>Hsu, Yuan-Ting</au><au>Lai, Ching-Huang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2019-11-29</date><risdate>2019</risdate><volume>16</volume><issue>23</issue><spage>4813</spage><pages>4813-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Oxidative stress plays a crucial role in the development of diseases induced by welding fumes. To our knowledge, little information is available on the relationship between multiple heavy metal exposure and oxidative stress in welders. We assessed the relationship between multiple heavy metal exposure and oxidative damage by analyzing 174 nonsmoking male welders in a shipyard. Urinary metals were used as the internal dose of exposure to metals in welding fumes, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers' metal levels and 8-OHdG was estimated using a multiple linear regression model. The geometric mean levels of urinary chromium (Cr), nickel (Ni), cadmium (Cd), and lead (Pb) were considerably higher in welders than in controls. Urinary Cr and Ni were determined as effective predictors of urinary 8-OHdG levels after adjusting for covariates. Oxidative DNA damage was associated with both Cr and Ni of welding fume exposure in shipyard welders (Ln Cr: β = 0.33, 95%C.I. = 0.16-0.49; Ln Ni: β = 0.27, 95%C.I. = 0.12-0.43). In this study, we investigated the significantly positive relationship between urinary metals (especially Cr and Ni) and 8-OHdG in nonsmoking shipyard welders. Moreover, the use of particulate respirators did not reduce metal exposure and oxidative damage. Therefore, we infer that hazard identification for welders should be conducted.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31795521</pmid><doi>10.3390/ijerph16234813</doi><orcidid>https://orcid.org/0000-0001-5097-8574</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 8-Hydroxy-2'-Deoxyguanosine - analysis Age Air Pollutants, Occupational - analysis Air Pollutants, Occupational - toxicity Biomarkers Biomarkers - urine Biomonitoring Cigarette smoking Creatinine Deoxyguanosine Deoxyribonucleic acid DNA DNA Damage Exposure Fumes Heavy metals Humans Linear Models Lung cancer Male Mass spectrometry Metal workers Metals, Heavy - analysis Metals, Heavy - toxicity Middle Aged Occupational exposure Occupational Exposure - analysis Organic chemistry Oxidative Stress Questionnaires Regression analysis Scientific imaging Shipyards Smoking Sociodemographics Statistical analysis Statistical methods Urine Welding Welding machines |
| title | Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine |
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