Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Infections induce complex host responses linked to antiviral defense, inflammation, and tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may orchestrate systemic metabolic changes during infection. We infected mice with chronic lymphocytic choriomeningitis virus...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-12, Vol.51 (6), p.1074-1087.e9
Hauptverfasser:	Lercher, Alexander, Bhattacharya, Anannya, Popa, Alexandra M., Caldera, Michael, Schlapansky, Moritz F., Baazim, Hatoon, Agerer, Benedikt, Gürtl, Bettina, Kosack, Lindsay, Májek, Peter, Brunner, Julia S., Vitko, Dijana, Pinter, Theresa, Genger, Jakob-Wendelin, Orlova, Anna, Pikor, Natalia, Reil, Daniela, Ozsvár-Kozma, Maria, Kalinke, Ulrich, Ludewig, Burkhard, Moriggl, Richard, Bennett, Keiryn L., Menche, Jörg, Cheng, Paul N., Schabbauer, Gernot, Trauner, Michael, Klavins, Kristaps, Bergthaler, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Arginine Arginine - blood CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8 T cells CD8-Positive T-Lymphocytes - immunology Cell Line Chlorocebus aethiops Chronic infection Cloning Cricetinae Cytokines Female Food Gene expression Gene sequencing Hepatitis hepatocyte Hepatocytes Hepatocytes - metabolism Homeostasis immunometabolism Immunoregulation infection Infections Inflammation Interferon Interferon Type I - immunology interferons Lipids Liver Liver - immunology Liver - metabolism Liver - virology Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Male Metabolism Metabolites Metabolomics Mice Mice, Inbred C57BL Mice, Knockout Ornithine Ornithine - blood Ornithine Carbamoyltransferase - genetics Pathogens Proteins Proteomics Receptor, Interferon alpha-beta - metabolism Ribonucleic acid RNA RNA viruses Signal Transduction - immunology Transcription Urea Urea - metabolism urea cycle Vero Cells Viral infections virus Viruses
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