Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane

The function of outer hair cells (OHCs), the mechanical actuators of the cochlea, involves the anchoring of their tallest stereocilia in the tectorial membrane (TM), an acellular structure overlying the sensory epithelium. Otogelin and otogelin-like are TM proteins related to secreted epithelial muc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-12, Vol.116 (51), p.25948-25957
Hauptverfasser:	Avan, Paul, Le Gal, Sébastien, Michel, Vincent, Dupont, Typhaine, Hardelin, Jean-Pierre, Petit, Christine, Verpy, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cochlea - cytology Deafness - congenital Deafness - genetics Deafness - metabolism Genetic Predisposition to Disease Hair Cells, Auditory, Outer - cytology Hair Cells, Auditory, Outer - metabolism Hair Cells, Vestibular - metabolism Hearing Loss, Sensorineural - congenital Hearing Loss, Sensorineural - genetics Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout Stereocilia - metabolism Tectorial Membrane - cytology Tectorial Membrane - metabolism
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