A population-based study of cardiovascular disease mortality risk in US cancer patients
Abstract Aims This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis. Methods and results The Surveillance, Epidemiology...
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| Veröffentlicht in: | European heart journal 2019-12, Vol.40 (48), p.3889-3897 |
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| creator | Sturgeon, Kathleen M Deng, Lei Bluethmann, Shirley M Zhou, Shouhao Trifiletti, Daniel M Jiang, Changchuan Kelly, Scott P Zaorsky, Nicholas G |
| description | Abstract
Aims
This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.
Methods and results
The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973–2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at |
| doi_str_mv | 10.1093/eurheartj/ehz766 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6925383</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehz766</oup_id><sourcerecordid>2317963181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4606-bafb0c5f2f0d919a013040ef2f81bc2c2b266016557a4b323a9d893c21de8d1e3</originalsourceid><addsrcrecordid>eNqFkc1LwzAYh4Mobn7cPUmOgtTlo82aizCGXzDwoENvIU1Sl9k1NWkH86830jn05CmEPO_ze8kPgDOMrjDidGQ6vzDSt8uRWXyOGdsDQ5wRknCWZvtgiDDPEsby1wE4CmGJEMoZZodgQPGYYZ5mQ_AygY1rukq21tVJIYPRMLSd3kBXQiW9tm4tg4qAh9oGEwG4cr6VlW030NvwDm0N50-RrZXxsIkiU7fhBByUsgrmdHseg_ntzfP0Ppk93j1MJ7NEpQyxGFgWSGUlKZHmmEuEKUqRifccF4ooUhDGEGZZNpZpQQmVXOecKoK1yTU29Bhc996mK1ZGq5jtZSUab1fSb4STVvx9qe1CvLm1YJxkNKdRcLEVePfRmdCKlQ3KVJWsjeuCIPGvOKM4xxFFPaq8C8GbcheDkfjuQ-z6EH0fceT893q7gZ8CInDZA65r_td9ASHam64</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317963181</pqid></control><display><type>article</type><title>A population-based study of cardiovascular disease mortality risk in US cancer patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Sturgeon, Kathleen M ; Deng, Lei ; Bluethmann, Shirley M ; Zhou, Shouhao ; Trifiletti, Daniel M ; Jiang, Changchuan ; Kelly, Scott P ; Zaorsky, Nicholas G</creator><creatorcontrib>Sturgeon, Kathleen M ; Deng, Lei ; Bluethmann, Shirley M ; Zhou, Shouhao ; Trifiletti, Daniel M ; Jiang, Changchuan ; Kelly, Scott P ; Zaorsky, Nicholas G</creatorcontrib><description>Abstract
Aims
This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.
Methods and results
The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973–2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at <35 years of age. Further, CVD mortality risk is highest (SMR 3.93, 95% confidence interval 3.89–3.97) within the first year after cancer diagnosis, and CVD mortality risk remains elevated throughout follow-up compared to the general population.
Conclusion
The majority of deaths from CVD occur in patients diagnosed with breast, prostate, or bladder cancer. We observed that from the point of cancer diagnosis forward into survivorship cancer patients (all sites) are at elevated risk of dying from CVDs compared to the general US population. In endometrial cancer, the first year after diagnosis poses a very high risk of dying from CVDs, supporting early involvement of cardiologists in such patients.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz766</identifier><identifier>PMID: 31761945</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aortic Aneurysm - pathology ; Aortic Dissection - complications ; Atherosclerosis - complications ; Breast Neoplasms - complications ; Breast Neoplasms - epidemiology ; Cancer Survivors - statistics & numerical data ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - mortality ; Case-Control Studies ; Cause of Death ; Cerebrovascular Disorders - complications ; Clinical Research ; Editor's Choice ; Endometrial Neoplasms - complications ; Endometrial Neoplasms - epidemiology ; Female ; Follow-Up Studies ; Heart Diseases - complications ; Humans ; Hypertension - complications ; Male ; Neoplasms - complications ; Neoplasms - epidemiology ; Neoplasms - mortality ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - epidemiology ; Research Design ; Risk Factors ; Time Factors ; United States - epidemiology ; Urinary Bladder Neoplasms - complications ; Urinary Bladder Neoplasms - epidemiology</subject><ispartof>European heart journal, 2019-12, Vol.40 (48), p.3889-3897</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4606-bafb0c5f2f0d919a013040ef2f81bc2c2b266016557a4b323a9d893c21de8d1e3</citedby><cites>FETCH-LOGICAL-c4606-bafb0c5f2f0d919a013040ef2f81bc2c2b266016557a4b323a9d893c21de8d1e3</cites><orcidid>0000-0001-9602-7897 ; 0000-0002-8124-5047</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,1586,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31761945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sturgeon, Kathleen M</creatorcontrib><creatorcontrib>Deng, Lei</creatorcontrib><creatorcontrib>Bluethmann, Shirley M</creatorcontrib><creatorcontrib>Zhou, Shouhao</creatorcontrib><creatorcontrib>Trifiletti, Daniel M</creatorcontrib><creatorcontrib>Jiang, Changchuan</creatorcontrib><creatorcontrib>Kelly, Scott P</creatorcontrib><creatorcontrib>Zaorsky, Nicholas G</creatorcontrib><title>A population-based study of cardiovascular disease mortality risk in US cancer patients</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Abstract
Aims
This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.
Methods and results
The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973–2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at <35 years of age. Further, CVD mortality risk is highest (SMR 3.93, 95% confidence interval 3.89–3.97) within the first year after cancer diagnosis, and CVD mortality risk remains elevated throughout follow-up compared to the general population.
Conclusion
The majority of deaths from CVD occur in patients diagnosed with breast, prostate, or bladder cancer. We observed that from the point of cancer diagnosis forward into survivorship cancer patients (all sites) are at elevated risk of dying from CVDs compared to the general US population. In endometrial cancer, the first year after diagnosis poses a very high risk of dying from CVDs, supporting early involvement of cardiologists in such patients.</description><subject>Aortic Aneurysm - pathology</subject><subject>Aortic Dissection - complications</subject><subject>Atherosclerosis - complications</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Cancer Survivors - statistics & numerical data</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Case-Control Studies</subject><subject>Cause of Death</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Clinical Research</subject><subject>Editor's Choice</subject><subject>Endometrial Neoplasms - complications</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Diseases - complications</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Male</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - mortality</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Research Design</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><subject>Urinary Bladder Neoplasms - complications</subject><subject>Urinary Bladder Neoplasms - epidemiology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LwzAYh4Mobn7cPUmOgtTlo82aizCGXzDwoENvIU1Sl9k1NWkH86830jn05CmEPO_ze8kPgDOMrjDidGQ6vzDSt8uRWXyOGdsDQ5wRknCWZvtgiDDPEsby1wE4CmGJEMoZZodgQPGYYZ5mQ_AygY1rukq21tVJIYPRMLSd3kBXQiW9tm4tg4qAh9oGEwG4cr6VlW030NvwDm0N50-RrZXxsIkiU7fhBByUsgrmdHseg_ntzfP0Ppk93j1MJ7NEpQyxGFgWSGUlKZHmmEuEKUqRifccF4ooUhDGEGZZNpZpQQmVXOecKoK1yTU29Bhc996mK1ZGq5jtZSUab1fSb4STVvx9qe1CvLm1YJxkNKdRcLEVePfRmdCKlQ3KVJWsjeuCIPGvOKM4xxFFPaq8C8GbcheDkfjuQ-z6EH0fceT893q7gZ8CInDZA65r_td9ASHam64</recordid><startdate>20191221</startdate><enddate>20191221</enddate><creator>Sturgeon, Kathleen M</creator><creator>Deng, Lei</creator><creator>Bluethmann, Shirley M</creator><creator>Zhou, Shouhao</creator><creator>Trifiletti, Daniel M</creator><creator>Jiang, Changchuan</creator><creator>Kelly, Scott P</creator><creator>Zaorsky, Nicholas G</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9602-7897</orcidid><orcidid>https://orcid.org/0000-0002-8124-5047</orcidid></search><sort><creationdate>20191221</creationdate><title>A population-based study of cardiovascular disease mortality risk in US cancer patients</title><author>Sturgeon, Kathleen M ; Deng, Lei ; Bluethmann, Shirley M ; Zhou, Shouhao ; Trifiletti, Daniel M ; Jiang, Changchuan ; Kelly, Scott P ; Zaorsky, Nicholas G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4606-bafb0c5f2f0d919a013040ef2f81bc2c2b266016557a4b323a9d893c21de8d1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aortic Aneurysm - pathology</topic><topic>Aortic Dissection - complications</topic><topic>Atherosclerosis - complications</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Cancer Survivors - statistics & numerical data</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Case-Control Studies</topic><topic>Cause of Death</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Clinical Research</topic><topic>Editor's Choice</topic><topic>Endometrial Neoplasms - complications</topic><topic>Endometrial Neoplasms - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Diseases - complications</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Male</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - mortality</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Research Design</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><topic>Urinary Bladder Neoplasms - complications</topic><topic>Urinary Bladder Neoplasms - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sturgeon, Kathleen M</creatorcontrib><creatorcontrib>Deng, Lei</creatorcontrib><creatorcontrib>Bluethmann, Shirley M</creatorcontrib><creatorcontrib>Zhou, Shouhao</creatorcontrib><creatorcontrib>Trifiletti, Daniel M</creatorcontrib><creatorcontrib>Jiang, Changchuan</creatorcontrib><creatorcontrib>Kelly, Scott P</creatorcontrib><creatorcontrib>Zaorsky, Nicholas G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sturgeon, Kathleen M</au><au>Deng, Lei</au><au>Bluethmann, Shirley M</au><au>Zhou, Shouhao</au><au>Trifiletti, Daniel M</au><au>Jiang, Changchuan</au><au>Kelly, Scott P</au><au>Zaorsky, Nicholas G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A population-based study of cardiovascular disease mortality risk in US cancer patients</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2019-12-21</date><risdate>2019</risdate><volume>40</volume><issue>48</issue><spage>3889</spage><epage>3897</epage><pages>3889-3897</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
Aims
This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.
Methods and results
The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973–2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at <35 years of age. Further, CVD mortality risk is highest (SMR 3.93, 95% confidence interval 3.89–3.97) within the first year after cancer diagnosis, and CVD mortality risk remains elevated throughout follow-up compared to the general population.
Conclusion
The majority of deaths from CVD occur in patients diagnosed with breast, prostate, or bladder cancer. We observed that from the point of cancer diagnosis forward into survivorship cancer patients (all sites) are at elevated risk of dying from CVDs compared to the general US population. In endometrial cancer, the first year after diagnosis poses a very high risk of dying from CVDs, supporting early involvement of cardiologists in such patients.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31761945</pmid><doi>10.1093/eurheartj/ehz766</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9602-7897</orcidid><orcidid>https://orcid.org/0000-0002-8124-5047</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aortic Aneurysm - pathology Aortic Dissection - complications Atherosclerosis - complications Breast Neoplasms - complications Breast Neoplasms - epidemiology Cancer Survivors - statistics & numerical data Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Case-Control Studies Cause of Death Cerebrovascular Disorders - complications Clinical Research Editor's Choice Endometrial Neoplasms - complications Endometrial Neoplasms - epidemiology Female Follow-Up Studies Heart Diseases - complications Humans Hypertension - complications Male Neoplasms - complications Neoplasms - epidemiology Neoplasms - mortality Prostatic Neoplasms - complications Prostatic Neoplasms - epidemiology Research Design Risk Factors Time Factors United States - epidemiology Urinary Bladder Neoplasms - complications Urinary Bladder Neoplasms - epidemiology |
| title | A population-based study of cardiovascular disease mortality risk in US cancer patients |
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