Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

Alzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those major pathological symptoms. Jatrorrhizine (JAT), a...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.19575-15, Article 19575
Hauptverfasser:	Wang, Sheng, Jiang, Wei, Ouyang, Ting, Shen, Xiu-Yin, Wang, Fen, Qu, Yu-hua, Zhang, Min, Luo, Tao, Wang, Hua-Qiao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/28 14/35 45/23 64/60 692/308/153 692/4017 692/617/375/365/1283 Abundance Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Analysis of Variance Animals Aquatic plants Astrocytes - drug effects Astrocytes - metabolism Berberine - analogs & derivatives Berberine - therapeutic use DNA sequencing DNA, Ribosomal - metabolism Dysbacteriosis Free radicals Gastrointestinal Microbiome - drug effects Herbal medicine Humanities and Social Sciences Inflammation Intestinal microflora Learning Learning - drug effects Male Maze Learning - drug effects Memory Disorders - drug therapy Mice Mice, Inbred C57BL Mice, Transgenic Microbiomes Microbiota multidisciplinary Neurodegenerative diseases Neuroprotection Oxidative stress Plaque, Amyloid - metabolism Presenilin 1 Public health Reactive oxygen species Rhizomes Rodents rRNA 16S Science Science (multidisciplinary) Senile plaques Transgenic animals Transgenic mice
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