High expression of fibronectin 1 indicates poor prognosis in gastric cancer
Fibronectin 1 ( ) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types. has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of and clinicopathological f...
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| Veröffentlicht in: | Oncology letters 2020-01, Vol.19 (1), p.93-102 |
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| creator | Sun, Yang Zhao, Chunlin Ye, Yanwei Wang, Zhen He, Yuanhang Li, Yulin Mao, Haoxun |
| description | Fibronectin 1 (
) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types.
has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of
and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between
expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition,
protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta-analysis results demonstrated an increase in
expression at the protein and mRNA level in GC tissues, and the
gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial
at the protein level was positively correlated with tumor size.
expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of
in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC. |
| doi_str_mv | 10.3892/ol.2019.11088 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6923922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A612031364</galeid><sourcerecordid>A612031364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-e4a3ce95716c09e7469a2a4ed7c2512f1826b6b40839edb6d0b2732cea77c7233</originalsourceid><addsrcrecordid>eNptksFvFCEUxomxsc3ao1dDYmK8zMqDWRguJk2j1tikFz0ThnkzSzMLI8wY-9-XtXXtGuHAC_ze9-DxEfIK2Fo0mr-P45oz0GsA1jTPyBkozasS8-eHWNWn5DznW1bGRkLTyBfkVECjFYA-I1-v_LCl-GtKmLOPgcae9r5NMaCbfaBAfei8szNmOsWY6JTiEGL2uRzQweY5eUedDQ7TS3LS2zHj-eO6It8_ffx2eVVd33z-cnlxXbkNiLnC2gqHeqNAOqZR1VJbbmvslOMb4D00XLayrVkjNHat7FjLleAOrVJOcSFW5MOD7rS0O-wchjnZ0UzJ72y6M9F6c3wS_NYM8aeRmgvNeRF49yiQ4o8F82x2PjscRxswLtmUGkIyJsp1V-TNP-htXFIoz9tTNUjJQP6lBjui8aGPpa7bi5oLCZwJELIu1Po_VJkd7rwrHe992T9KePskYYt2nLc5jstcPiofg9UD6FLMOWF_aAYws3eKiaPZO8X8dkrhXz_t4IH-4wtxDyTutmU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2334166016</pqid></control><display><type>article</type><title>High expression of fibronectin 1 indicates poor prognosis in gastric cancer</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Sun, Yang ; Zhao, Chunlin ; Ye, Yanwei ; Wang, Zhen ; He, Yuanhang ; Li, Yulin ; Mao, Haoxun</creator><creatorcontrib>Sun, Yang ; Zhao, Chunlin ; Ye, Yanwei ; Wang, Zhen ; He, Yuanhang ; Li, Yulin ; Mao, Haoxun</creatorcontrib><description>Fibronectin 1 (
) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types.
has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of
and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between
expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition,
protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta-analysis results demonstrated an increase in
expression at the protein and mRNA level in GC tissues, and the
gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial
at the protein level was positively correlated with tumor size.
expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of
in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2019.11088</identifier><identifier>PMID: 31897119</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Analysis ; Biochemistry ; Biomarkers ; Cancer ; Cancer genetics ; Cancer research ; Cell adhesion & migration ; Data analysis ; Datasets ; Development and progression ; Fibronectins ; Gastric cancer ; Gene expression ; Genes ; Genetic aspects ; Genomes ; Genomics ; Immunohistochemistry ; Medical prognosis ; Messenger RNA ; Meta-analysis ; Mortality ; Oncology ; Prognosis ; RNA ; Statistical analysis ; Stomach cancer ; Surgery ; Survival analysis ; Tumors</subject><ispartof>Oncology letters, 2020-01, Vol.19 (1), p.93-102</ispartof><rights>Copyright: © Sun et al.</rights><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Sun et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-e4a3ce95716c09e7469a2a4ed7c2512f1826b6b40839edb6d0b2732cea77c7233</citedby><cites>FETCH-LOGICAL-c513t-e4a3ce95716c09e7469a2a4ed7c2512f1826b6b40839edb6d0b2732cea77c7233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923922/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923922/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Zhao, Chunlin</creatorcontrib><creatorcontrib>Ye, Yanwei</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>He, Yuanhang</creatorcontrib><creatorcontrib>Li, Yulin</creatorcontrib><creatorcontrib>Mao, Haoxun</creatorcontrib><title>High expression of fibronectin 1 indicates poor prognosis in gastric cancer</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Fibronectin 1 (
) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types.
has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of
and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between
expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition,
protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta-analysis results demonstrated an increase in
expression at the protein and mRNA level in GC tissues, and the
gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial
at the protein level was positively correlated with tumor size.
expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of
in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC.</description><subject>Analysis</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Cancer research</subject><subject>Cell adhesion & migration</subject><subject>Data analysis</subject><subject>Datasets</subject><subject>Development and progression</subject><subject>Fibronectins</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Immunohistochemistry</subject><subject>Medical prognosis</subject><subject>Messenger RNA</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>RNA</subject><subject>Statistical analysis</subject><subject>Stomach cancer</subject><subject>Surgery</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptksFvFCEUxomxsc3ao1dDYmK8zMqDWRguJk2j1tikFz0ThnkzSzMLI8wY-9-XtXXtGuHAC_ze9-DxEfIK2Fo0mr-P45oz0GsA1jTPyBkozasS8-eHWNWn5DznW1bGRkLTyBfkVECjFYA-I1-v_LCl-GtKmLOPgcae9r5NMaCbfaBAfei8szNmOsWY6JTiEGL2uRzQweY5eUedDQ7TS3LS2zHj-eO6It8_ffx2eVVd33z-cnlxXbkNiLnC2gqHeqNAOqZR1VJbbmvslOMb4D00XLayrVkjNHat7FjLleAOrVJOcSFW5MOD7rS0O-wchjnZ0UzJ72y6M9F6c3wS_NYM8aeRmgvNeRF49yiQ4o8F82x2PjscRxswLtmUGkIyJsp1V-TNP-htXFIoz9tTNUjJQP6lBjui8aGPpa7bi5oLCZwJELIu1Po_VJkd7rwrHe992T9KePskYYt2nLc5jstcPiofg9UD6FLMOWF_aAYws3eKiaPZO8X8dkrhXz_t4IH-4wtxDyTutmU</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Sun, Yang</creator><creator>Zhao, Chunlin</creator><creator>Ye, Yanwei</creator><creator>Wang, Zhen</creator><creator>He, Yuanhang</creator><creator>Li, Yulin</creator><creator>Mao, Haoxun</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>High expression of fibronectin 1 indicates poor prognosis in gastric cancer</title><author>Sun, Yang ; Zhao, Chunlin ; Ye, Yanwei ; Wang, Zhen ; He, Yuanhang ; Li, Yulin ; Mao, Haoxun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-e4a3ce95716c09e7469a2a4ed7c2512f1826b6b40839edb6d0b2732cea77c7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Cancer research</topic><topic>Cell adhesion & migration</topic><topic>Data analysis</topic><topic>Datasets</topic><topic>Development and progression</topic><topic>Fibronectins</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Immunohistochemistry</topic><topic>Medical prognosis</topic><topic>Messenger RNA</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>RNA</topic><topic>Statistical analysis</topic><topic>Stomach cancer</topic><topic>Surgery</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Zhao, Chunlin</creatorcontrib><creatorcontrib>Ye, Yanwei</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>He, Yuanhang</creatorcontrib><creatorcontrib>Li, Yulin</creatorcontrib><creatorcontrib>Mao, Haoxun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yang</au><au>Zhao, Chunlin</au><au>Ye, Yanwei</au><au>Wang, Zhen</au><au>He, Yuanhang</au><au>Li, Yulin</au><au>Mao, Haoxun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High expression of fibronectin 1 indicates poor prognosis in gastric cancer</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>19</volume><issue>1</issue><spage>93</spage><epage>102</epage><pages>93-102</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Fibronectin 1 (
) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types.
has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of
and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between
expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition,
protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta-analysis results demonstrated an increase in
expression at the protein and mRNA level in GC tissues, and the
gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial
at the protein level was positively correlated with tumor size.
expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of
in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31897119</pmid><doi>10.3892/ol.2019.11088</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology letters, 2020-01, Vol.19 (1), p.93-102 |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis Biochemistry Biomarkers Cancer Cancer genetics Cancer research Cell adhesion & migration Data analysis Datasets Development and progression Fibronectins Gastric cancer Gene expression Genes Genetic aspects Genomes Genomics Immunohistochemistry Medical prognosis Messenger RNA Meta-analysis Mortality Oncology Prognosis RNA Statistical analysis Stomach cancer Surgery Survival analysis Tumors |
| title | High expression of fibronectin 1 indicates poor prognosis in gastric cancer |
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