Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway

Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with traditional Chinese medicine. Ganoderma lucidum, a traditional Chinese medicine with antitumor effects, offers a potential alternative, but little is known about its...

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Veröffentlicht in:	Integrative cancer therapies 2019, Vol.18, p.1534735419890917-1534735419890917
Hauptverfasser:	Zhang, Qi-Hao, Hu, Qin-Xiao, Xie, Da, Chang, Bo, Miao, Hou-Guang, Wang, Yun-Guo, Liu, De-Zhong, Li, Xue-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Antitumor activity Apoptosis Apoptosis - drug effects beta Catenin - metabolism Biological Products - pharmacology Bone cancer c-Myc protein Cell Cycle - drug effects Cell Death - drug effects Cell growth Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chinese medicine Cyclin D1 E-cadherin Flow cytometry Ganoderma lucidum Gelatinase A Gelatinase B Gene Expression Regulation, Neoplastic - drug effects Humans Leukocyte migration LRP5 protein Lymphocytes T Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Molecular modelling Myc protein Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma cells Polymerase chain reaction Propidium iodide Reishi - chemistry Sarcoma Signal transduction Traditional Chinese medicine Transcription factors Wnt Signaling Pathway - drug effects Wound healing
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