KRAS4A directly regulates hexokinase 1

The most frequently mutated oncogene in cancer is KRAS , which uses alternative fourth exons to generate two gene products (KRAS4A and KRAS4B) that differ only in their C-terminal membrane-targeting region 1 . Because oncogenic mutations occur in exons 2 or 3, two constitutively active KRAS proteins...

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Veröffentlicht in:	Nature (London) 2019-12, Vol.576 (7787), p.482-486
Hauptverfasser:	Amendola, Caroline R., Mahaffey, James P., Parker, Seth J., Ahearn, Ian M., Chen, Wei-Ching, Zhou, Mo, Court, Helen, Shi, Jie, Mendoza, Sebastian L., Morten, Michael J., Rothenberg, Eli, Gottlieb, Eyal, Wadghiri, Youssef Z., Possemato, Richard, Hubbard, Stevan R., Balmain, Allan, Kimmelman, Alec C., Philips, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/89 13/95 14/19 59 631/67/2327 631/80/86 82/29 82/58 82/80 Allosteric Regulation Alternative splicing Amino acids Animals Cancer Cell Line, Tumor Colorectal cancer Competition Enzyme Activation Enzymes Exons Genetic regulation Glucose Glycolysis Guanosine triphosphate Guanosine Triphosphate - metabolism Health aspects Hexokinase Hexokinase - chemistry Hexokinase - metabolism Humanities and Social Sciences Humans In Vitro Techniques Isoenzymes - metabolism K-Ras protein Kinases Lipoylation Male Membranes Metabolism Mice Mitochondria Mitochondria - enzymology Mitochondria - metabolism Mitochondrial Membranes - enzymology Mitochondrial Membranes - metabolism multidisciplinary Mutation Neoplasms - enzymology Neoplasms - metabolism Oncogenes Palmitoylation Phosphotransferases Physiological aspects Protein Binding Protein Transport Proteins Proto-Oncogene Proteins p21(ras) - metabolism Science Science (multidisciplinary) Transcription Tumors
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