Electrostatic Complementarity Drives Amyloid/Nucleic Acid Co‐Assembly

Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion‐induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co‐assemblies remain...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-01, Vol.59 (1), p.358-363
Hauptverfasser:	Rha, Allisandra K., Das, Dibyendu, Taran, Olga, Ke, Yonggang, Mehta, Anil K., Lynn, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alzheimer's disease Amyloid - chemistry Assembly Biopolymers Complementarity Etiology Fibrillation Glycosaminoglycans Humans Models, Molecular Neurodegenerative diseases nucleic acid/amyloid co-assembly Nucleic acids Peptide Nucleic Acids - chemistry Peptides Plaques Polyanions Polyelectrolytes solid-state NMR spectroscopy Static Electricity Structural models
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