Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect
In this study, an efficient polysaccharide, named CAL-n (Crinum asiaticum L.-n) was isolated and purified from Crinum asiaticum L for the first time, Mw(molecular weight) of 730,000 Da. CAL-n comprised Rha(rhamnose), Sor(sorbose), Gal(galactose) and Glu(glucosein) the molar ratio of 1:61.6:1.66:4.74...
Gespeichert in:
| Veröffentlicht in: | Saudi journal of biological sciences 2019-12, Vol.26 (8), p.2085-2090 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2090 |
|---|---|
| container_issue | 8 |
| container_start_page | 2085 |
| container_title | Saudi journal of biological sciences |
| container_volume | 26 |
| creator | Yu, Miao Chen, Yingxiang Liu, Yingjie Yu, Miao Xu, Ying Wang, Bing |
| description | In this study, an efficient polysaccharide, named CAL-n (Crinum asiaticum L.-n) was isolated and purified from Crinum asiaticum L for the first time, Mw(molecular weight) of 730,000 Da. CAL-n comprised Rha(rhamnose), Sor(sorbose), Gal(galactose) and Glu(glucosein) the molar ratio of 1:61.6:1.66:4.74. The chemical structure of CAL-n was studied by Infrared spectrum and GC–MS(Gas Chromatography–Mass Spectrometer) analysis. Experimental results reflected, that the backbone of CAL-n comprised (1 → 2), (1 → 6), (1 → 3) beta-pyran glycoside bond, without (1 → 4) beta-pyran glycoside bond. In addition, an MTT assay indicated that the growth of HepG2 cells was affected by CAL-n, with a concentration dependant ration. The results indicated that CAL-n should by exploration as anti-tumor activities in vivo. |
| doi_str_mv | 10.1016/j.sjbs.2019.09.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6923459</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1319562X19301792</els_id><sourcerecordid>2331633761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-7a46a855379746bb78b914817c474c31ee7b988cf0ba0ed9ebcb3549ba62cd483</originalsourceid><addsrcrecordid>eNp9UcuqFDEQDaJ4x6s_ICi9dNNtqtOdB4ggw_UBA24U3IUknTgZujtjkr5wXfkb_p5fYpoZB90IFVLknFNVqYPQU8ANYKAvD0066NS0GESDSwC7hzZtC6RmgOl9tAECou5p--UKPUrpgDHlhMNDdEWAc8GE2KD9jXPeeDvn6hjGu6SM2avoB5sqF8NUbaOfl6lSyavsTcl2za8fP1OVclxMXqIaq1WgTLbRfy-cMFdqHsrJvs7LFGJlnbMmP0YPnBqTfXK-r9Hntzeftu_r3cd3H7ZvdrXpGMs1Ux1VvO8JE6yjWjOuBXQcWIE7Q8BapgXnxmGtsB2E1UaTvhNa0dYMHSfX6PWp7nHRkx1M-VkZUh6jn1S8k0F5-S8y-738Gm4lFS3pelEKvDgXiOHbYlOWk0_GjqOabViSbAkBSgijUKjtiWpiSClad2kDWK4WyYNcLZKrRRKXAFZEz_8e8CL540khPDsRbHm3Tl0YAnDP-4K_OuNljbfeRplWA40dfCyLlkPw_-v_G2VgsQI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2331633761</pqid></control><display><type>article</type><title>Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect</title><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Yu, Miao ; Chen, Yingxiang ; Liu, Yingjie ; Yu, Miao ; Xu, Ying ; Wang, Bing</creator><creatorcontrib>Yu, Miao ; Chen, Yingxiang ; Liu, Yingjie ; Yu, Miao ; Xu, Ying ; Wang, Bing</creatorcontrib><description>In this study, an efficient polysaccharide, named CAL-n (Crinum asiaticum L.-n) was isolated and purified from Crinum asiaticum L for the first time, Mw(molecular weight) of 730,000 Da. CAL-n comprised Rha(rhamnose), Sor(sorbose), Gal(galactose) and Glu(glucosein) the molar ratio of 1:61.6:1.66:4.74. The chemical structure of CAL-n was studied by Infrared spectrum and GC–MS(Gas Chromatography–Mass Spectrometer) analysis. Experimental results reflected, that the backbone of CAL-n comprised (1 → 2), (1 → 6), (1 → 3) beta-pyran glycoside bond, without (1 → 4) beta-pyran glycoside bond. In addition, an MTT assay indicated that the growth of HepG2 cells was affected by CAL-n, with a concentration dependant ration. The results indicated that CAL-n should by exploration as anti-tumor activities in vivo.</description><identifier>ISSN: 1319-562X</identifier><identifier>EISSN: 2213-7106</identifier><identifier>DOI: 10.1016/j.sjbs.2019.09.017</identifier><identifier>PMID: 31889799</identifier><language>eng</language><publisher>Riyadh, Saudi Arabia: Elsevier B.V</publisher><subject>Antitumor activity ; Crinum asiaticum L ; Polysaccharides ; Structure ; الأدوية المضادة للأورام ; السرطان ; العلاج المناعي ; متعدد السكاريد</subject><ispartof>Saudi journal of biological sciences, 2019-12, Vol.26 (8), p.2085-2090</ispartof><rights>2019</rights><rights>2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.</rights><rights>2019 Production and hosting by Elsevier B.V. on behalf of King Saud University. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-7a46a855379746bb78b914817c474c31ee7b988cf0ba0ed9ebcb3549ba62cd483</citedby><cites>FETCH-LOGICAL-c477t-7a46a855379746bb78b914817c474c31ee7b988cf0ba0ed9ebcb3549ba62cd483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923459/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.sjbs.2019.09.017$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31889799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Chen, Yingxiang</creatorcontrib><creatorcontrib>Liu, Yingjie</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><title>Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect</title><title>Saudi journal of biological sciences</title><addtitle>Saudi J Biol Sci</addtitle><description>In this study, an efficient polysaccharide, named CAL-n (Crinum asiaticum L.-n) was isolated and purified from Crinum asiaticum L for the first time, Mw(molecular weight) of 730,000 Da. CAL-n comprised Rha(rhamnose), Sor(sorbose), Gal(galactose) and Glu(glucosein) the molar ratio of 1:61.6:1.66:4.74. The chemical structure of CAL-n was studied by Infrared spectrum and GC–MS(Gas Chromatography–Mass Spectrometer) analysis. Experimental results reflected, that the backbone of CAL-n comprised (1 → 2), (1 → 6), (1 → 3) beta-pyran glycoside bond, without (1 → 4) beta-pyran glycoside bond. In addition, an MTT assay indicated that the growth of HepG2 cells was affected by CAL-n, with a concentration dependant ration. The results indicated that CAL-n should by exploration as anti-tumor activities in vivo.</description><subject>Antitumor activity</subject><subject>Crinum asiaticum L</subject><subject>Polysaccharides</subject><subject>Structure</subject><subject>الأدوية المضادة للأورام</subject><subject>السرطان</subject><subject>العلاج المناعي</subject><subject>متعدد السكاريد</subject><issn>1319-562X</issn><issn>2213-7106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UcuqFDEQDaJ4x6s_ICi9dNNtqtOdB4ggw_UBA24U3IUknTgZujtjkr5wXfkb_p5fYpoZB90IFVLknFNVqYPQU8ANYKAvD0066NS0GESDSwC7hzZtC6RmgOl9tAECou5p--UKPUrpgDHlhMNDdEWAc8GE2KD9jXPeeDvn6hjGu6SM2avoB5sqF8NUbaOfl6lSyavsTcl2za8fP1OVclxMXqIaq1WgTLbRfy-cMFdqHsrJvs7LFGJlnbMmP0YPnBqTfXK-r9Hntzeftu_r3cd3H7ZvdrXpGMs1Ux1VvO8JE6yjWjOuBXQcWIE7Q8BapgXnxmGtsB2E1UaTvhNa0dYMHSfX6PWp7nHRkx1M-VkZUh6jn1S8k0F5-S8y-738Gm4lFS3pelEKvDgXiOHbYlOWk0_GjqOabViSbAkBSgijUKjtiWpiSClad2kDWK4WyYNcLZKrRRKXAFZEz_8e8CL540khPDsRbHm3Tl0YAnDP-4K_OuNljbfeRplWA40dfCyLlkPw_-v_G2VgsQI</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Yu, Miao</creator><creator>Chen, Yingxiang</creator><creator>Liu, Yingjie</creator><creator>Yu, Miao</creator><creator>Xu, Ying</creator><creator>Wang, Bing</creator><general>Elsevier B.V</general><general>Saudi Biological Society</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191201</creationdate><title>Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect</title><author>Yu, Miao ; Chen, Yingxiang ; Liu, Yingjie ; Yu, Miao ; Xu, Ying ; Wang, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-7a46a855379746bb78b914817c474c31ee7b988cf0ba0ed9ebcb3549ba62cd483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antitumor activity</topic><topic>Crinum asiaticum L</topic><topic>Polysaccharides</topic><topic>Structure</topic><topic>الأدوية المضادة للأورام</topic><topic>السرطان</topic><topic>العلاج المناعي</topic><topic>متعدد السكاريد</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Chen, Yingxiang</creatorcontrib><creatorcontrib>Liu, Yingjie</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Miao</au><au>Chen, Yingxiang</au><au>Liu, Yingjie</au><au>Yu, Miao</au><au>Xu, Ying</au><au>Wang, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect</atitle><jtitle>Saudi journal of biological sciences</jtitle><addtitle>Saudi J Biol Sci</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>26</volume><issue>8</issue><spage>2085</spage><epage>2090</epage><pages>2085-2090</pages><issn>1319-562X</issn><eissn>2213-7106</eissn><abstract>In this study, an efficient polysaccharide, named CAL-n (Crinum asiaticum L.-n) was isolated and purified from Crinum asiaticum L for the first time, Mw(molecular weight) of 730,000 Da. CAL-n comprised Rha(rhamnose), Sor(sorbose), Gal(galactose) and Glu(glucosein) the molar ratio of 1:61.6:1.66:4.74. The chemical structure of CAL-n was studied by Infrared spectrum and GC–MS(Gas Chromatography–Mass Spectrometer) analysis. Experimental results reflected, that the backbone of CAL-n comprised (1 → 2), (1 → 6), (1 → 3) beta-pyran glycoside bond, without (1 → 4) beta-pyran glycoside bond. In addition, an MTT assay indicated that the growth of HepG2 cells was affected by CAL-n, with a concentration dependant ration. The results indicated that CAL-n should by exploration as anti-tumor activities in vivo.</abstract><cop>Riyadh, Saudi Arabia</cop><pub>Elsevier B.V</pub><pmid>31889799</pmid><doi>10.1016/j.sjbs.2019.09.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1319-562X |
| ispartof | Saudi journal of biological sciences, 2019-12, Vol.26 (8), p.2085-2090 |
| issn | 1319-562X 2213-7106 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6923459 |
| source | ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antitumor activity Crinum asiaticum L Polysaccharides Structure الأدوية المضادة للأورام السرطان العلاج المناعي متعدد السكاريد |
| title | Efficient polysaccharides from Crinum asiaticum L.’s structural characterization and anti-tumor effect |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A37%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficient%20polysaccharides%20from%20Crinum%20asiaticum%20L.%E2%80%99s%20structural%20characterization%20and%20anti-tumor%20effect&rft.jtitle=Saudi%20journal%20of%20biological%20sciences&rft.au=Yu,%20Miao&rft.date=2019-12-01&rft.volume=26&rft.issue=8&rft.spage=2085&rft.epage=2090&rft.pages=2085-2090&rft.issn=1319-562X&rft.eissn=2213-7106&rft_id=info:doi/10.1016/j.sjbs.2019.09.017&rft_dat=%3Cproquest_pubme%3E2331633761%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2331633761&rft_id=info:pmid/31889799&rft_els_id=S1319562X19301792&rfr_iscdi=true |