High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China
Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-12, Vol.98 (50), p.e18405-e18405 |
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| creator | Zhou, Guoyu Liu, Shuangwu Yu, Xiaolin Zhao, Xinjin Ma, Lin Shan, Peiyan |
| description | Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Eastern China and to assess the relationship among sleep disorder, BPSD, and cognition.A total of 176 participants were enrolled in the study, including 84 AD patients and 92 healthy individuals as controls. Mini-mental state examination (MMSE), cooperative study-activities of daily living (ADCS-ADL) and clinical dementia rating (CDR) were used to measure cognition, the competence in basic and instrumental activities of daily living, and severity of dementia, respectively. BPSD were evaluated by neuropsychiatric inventory (NPI). Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale were designed to assess the sleep status and daytime naps. Spearman correlation analyses were performed to determine the relations between PSQI, MMSE, ADCS-ADL, and NPI scores and CDR.Sleep disorders occurred in 55.9% of AD patients versus only 15.2% of controls. 89.2% of AD patients had BPSD while only 22.9% of controls did, with apathy (64.2%) the most common among AD patients. Among AD patients, PSQI was negatively correlated with both MMSE (r = -0.600, P |
| doi_str_mv | 10.1097/MD.0000000000018405 |
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Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Eastern China and to assess the relationship among sleep disorder, BPSD, and cognition.A total of 176 participants were enrolled in the study, including 84 AD patients and 92 healthy individuals as controls. Mini-mental state examination (MMSE), cooperative study-activities of daily living (ADCS-ADL) and clinical dementia rating (CDR) were used to measure cognition, the competence in basic and instrumental activities of daily living, and severity of dementia, respectively. BPSD were evaluated by neuropsychiatric inventory (NPI). Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale were designed to assess the sleep status and daytime naps. Spearman correlation analyses were performed to determine the relations between PSQI, MMSE, ADCS-ADL, and NPI scores and CDR.Sleep disorders occurred in 55.9% of AD patients versus only 15.2% of controls. 89.2% of AD patients had BPSD while only 22.9% of controls did, with apathy (64.2%) the most common among AD patients. Among AD patients, PSQI was negatively correlated with both MMSE (r = -0.600, P < .01) and ADCS-ADL (r = -0.725, P < .01), and was positively correlated with total NPI score (r = 0.608, P < .01). PSQI was closely associated with depression (r = 0.653, P < .01) and apathy (r = 0.604, P < .01).This study showed that AD patients have a higher prevalence of sleep disorders and BPSD than healthy elderly adults. Sleep disorders affect cognition of AD patients and increase apathy and depression. These results can help investigate new therapeutic targets in AD treatments.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000018405</identifier><identifier>PMID: 31852160</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Activities of Daily Living ; Aged ; Alzheimer Disease - epidemiology ; Behavioral Symptoms - epidemiology ; Case-Control Studies ; China - epidemiology ; Female ; Humans ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Observational Study ; Prevalence ; Severity of Illness Index ; Sleep Wake Disorders - epidemiology</subject><ispartof>Medicine (Baltimore), 2019-12, Vol.98 (50), p.e18405-e18405</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3550-c4616ee8c40431af374dbe261bbdde1a0c0aebb65a95146b516bfa61c1111e0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922506/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922506/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31852160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Guoyu</creatorcontrib><creatorcontrib>Liu, Shuangwu</creatorcontrib><creatorcontrib>Yu, Xiaolin</creatorcontrib><creatorcontrib>Zhao, Xinjin</creatorcontrib><creatorcontrib>Ma, Lin</creatorcontrib><creatorcontrib>Shan, Peiyan</creatorcontrib><title>High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Eastern China and to assess the relationship among sleep disorder, BPSD, and cognition.A total of 176 participants were enrolled in the study, including 84 AD patients and 92 healthy individuals as controls. Mini-mental state examination (MMSE), cooperative study-activities of daily living (ADCS-ADL) and clinical dementia rating (CDR) were used to measure cognition, the competence in basic and instrumental activities of daily living, and severity of dementia, respectively. BPSD were evaluated by neuropsychiatric inventory (NPI). Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale were designed to assess the sleep status and daytime naps. Spearman correlation analyses were performed to determine the relations between PSQI, MMSE, ADCS-ADL, and NPI scores and CDR.Sleep disorders occurred in 55.9% of AD patients versus only 15.2% of controls. 89.2% of AD patients had BPSD while only 22.9% of controls did, with apathy (64.2%) the most common among AD patients. Among AD patients, PSQI was negatively correlated with both MMSE (r = -0.600, P < .01) and ADCS-ADL (r = -0.725, P < .01), and was positively correlated with total NPI score (r = 0.608, P < .01). PSQI was closely associated with depression (r = 0.653, P < .01) and apathy (r = 0.604, P < .01).This study showed that AD patients have a higher prevalence of sleep disorders and BPSD than healthy elderly adults. Sleep disorders affect cognition of AD patients and increase apathy and depression. These results can help investigate new therapeutic targets in AD treatments.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Behavioral Symptoms - epidemiology</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mental Status and Dementia Tests</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Prevalence</subject><subject>Severity of Illness Index</subject><subject>Sleep Wake Disorders - epidemiology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1DAUhS0EokPhCZCQl2zS-j8TFkijaaFIrdjA2nKcm4nBiYOdTDU8Bk-M02nLz91Yts_57rUPQq8pOaOkKs9vLs7In6JrQeQTtKKSq0JWSjxFK0KYLMqqFCfoRUrfsoiXTDxHJ5yuJaOKrNCvK7fr8BhhbzwMFnBocfIAI25cCrGBmLAZGlxDZ_YuROPvtmM62C74sHM2n6RDP06hT4u5gR6GyRnsBuzNBEUYEkx443924HqICxdMgnd4g9M0N4dFeGnSBHHA284N5iV61hqf4NX9eoq-frj8sr0qrj9__LTdXBeWS0kKKxRVAGsriODUtLwUTQ1M0bpuGqCGWGKgrpU0laRC1ZKqujWKWpoLSM1P0fsjd5zrHhqbx87P02N0vYkHHYzT_94MrtO7sNeqYkwSlQFv7wEx_JghTbp3yYL3ZoAwJ804W5elqugi5UepjSGlCO1jG0r0kqa-udD_p5ldb_6e8NHzEF8WiKPgNvj8gem7n28h6g6Mn7o7niwrVjBCK8ooJ0UmE8J_A6ckrdQ</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Zhou, Guoyu</creator><creator>Liu, Shuangwu</creator><creator>Yu, Xiaolin</creator><creator>Zhao, Xinjin</creator><creator>Ma, Lin</creator><creator>Shan, Peiyan</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191201</creationdate><title>High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China</title><author>Zhou, Guoyu ; Liu, Shuangwu ; Yu, Xiaolin ; Zhao, Xinjin ; Ma, Lin ; Shan, Peiyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3550-c4616ee8c40431af374dbe261bbdde1a0c0aebb65a95146b516bfa61c1111e0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Activities of Daily Living</topic><topic>Aged</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Behavioral Symptoms - epidemiology</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Status and Dementia Tests</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Prevalence</topic><topic>Severity of Illness Index</topic><topic>Sleep Wake Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Guoyu</creatorcontrib><creatorcontrib>Liu, Shuangwu</creatorcontrib><creatorcontrib>Yu, Xiaolin</creatorcontrib><creatorcontrib>Zhao, Xinjin</creatorcontrib><creatorcontrib>Ma, Lin</creatorcontrib><creatorcontrib>Shan, Peiyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Guoyu</au><au>Liu, Shuangwu</au><au>Yu, Xiaolin</au><au>Zhao, Xinjin</au><au>Ma, Lin</au><au>Shan, Peiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>98</volume><issue>50</issue><spage>e18405</spage><epage>e18405</epage><pages>e18405-e18405</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Eastern China and to assess the relationship among sleep disorder, BPSD, and cognition.A total of 176 participants were enrolled in the study, including 84 AD patients and 92 healthy individuals as controls. Mini-mental state examination (MMSE), cooperative study-activities of daily living (ADCS-ADL) and clinical dementia rating (CDR) were used to measure cognition, the competence in basic and instrumental activities of daily living, and severity of dementia, respectively. BPSD were evaluated by neuropsychiatric inventory (NPI). Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale were designed to assess the sleep status and daytime naps. Spearman correlation analyses were performed to determine the relations between PSQI, MMSE, ADCS-ADL, and NPI scores and CDR.Sleep disorders occurred in 55.9% of AD patients versus only 15.2% of controls. 89.2% of AD patients had BPSD while only 22.9% of controls did, with apathy (64.2%) the most common among AD patients. Among AD patients, PSQI was negatively correlated with both MMSE (r = -0.600, P < .01) and ADCS-ADL (r = -0.725, P < .01), and was positively correlated with total NPI score (r = 0.608, P < .01). PSQI was closely associated with depression (r = 0.653, P < .01) and apathy (r = 0.604, P < .01).This study showed that AD patients have a higher prevalence of sleep disorders and BPSD than healthy elderly adults. Sleep disorders affect cognition of AD patients and increase apathy and depression. These results can help investigate new therapeutic targets in AD treatments.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31852160</pmid><doi>10.1097/MD.0000000000018405</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Activities of Daily Living Aged Alzheimer Disease - epidemiology Behavioral Symptoms - epidemiology Case-Control Studies China - epidemiology Female Humans Male Mental Status and Dementia Tests Middle Aged Observational Study Prevalence Severity of Illness Index Sleep Wake Disorders - epidemiology |
| title | High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease: A study in Eastern China |
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