Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model

Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1 +/− mice, a model of sporadic Parkinson’s disease. We found that the GM1 oligosaccharide, systemicall...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.19330-15, Article 19330
Hauptverfasser:	Chiricozzi, Elena, Mauri, Laura, Lunghi, Giulia, Di Biase, Erika, Fazzari, Maria, Maggioni, Margherita, Valsecchi, Manuela, Prioni, Simona, Loberto, Nicoletta, Pomè, Diego Yuri, Ciampa, Maria Grazia, Fato, Pamela, Verlengia, Gianluca, Cattaneo, Stefano, Assini, Robert, Wu, Gusheng, Alselehdar, Samar, Ledeen, Robert W., Sonnino, Sandro
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/1 14/63 631/378/1689 64/60 692/308/2778 82/1 alpha-Synuclein - metabolism Animals Disease Models, Animal Female Hand Strength Humanities and Social Sciences Male Mice, Inbred C57BL Motor Activity - drug effects Movement disorders multidisciplinary N-Acetylgalactosaminyltransferases - metabolism Neurodegenerative diseases Neurotransmitter Agents - metabolism Oligosaccharides Oligosaccharides - pharmacology Oligosaccharides - therapeutic use Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson's disease Science Science (multidisciplinary) Substantia Nigra - drug effects Substantia Nigra - enzymology Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism
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