Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 inflammation with accumulation of activated group 2 innate lymphoid cells (ILC2s) and elevation of thymic stromal lymphopoietin (TSLP). A member of the TNF superfamily (TNFSF), TNFSF15, is known to induce the production of...

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Veröffentlicht in:Mucosal immunology 2020-01, Vol.13 (1), p.86-95
Hauptverfasser: Ogasawara, Noriko, Poposki, Julie A., Klingler, Aiko I., Tan, Bruce K., Hulse, Kathryn E., Stevens, Whitney W., Peters, Anju T., Grammer, Leslie C., Welch, Kevin C., Smith, Stephanie S., Conley, David B., Raviv, Joseph R., Soroosh, Pejman, Takano, Ken-ichi, Himi, Tetsuo, Kern, Robert C., Schleimer, Robert P., Kato, Atsushi
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Sprache:eng
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