Chitinase 3‐like 1 deficiency ameliorates liver fibrosis by promoting hepatic macrophage apoptosis

Aim Chitinase 3‐like 1 (CHI3L1), an 18‐glycosyl hydrolase‐related molecule, is a member of the enzymatically inactive chitinase‐like protein family. Serum levels of CHI3L1 are strongly correlated with hepatic fibrosis progression during many liver diseases. Therefore, this protein could be involved...

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Veröffentlicht in:	Hepatology research 2019-11, Vol.49 (11), p.1316-1328
Hauptverfasser:	Higashiyama, Masaaki, Tomita, Kengo, Sugihara, Nao, Nakashima, Hiroyuki, Furuhashi, Hirotaka, Nishikawa, Makoto, Inaba, Kenichi, Wada, Akinori, Horiuchi, Kazuki, Hanawa, Yoshinori, Shibuya, Naoki, Kurihara, Chie, Okada, Yoshikiyo, Nishii, Shin, Mizoguchi, Akinori, Hozumi, Hideaki, Watanabe, Chikako, Komoto, Shunsuke, Yamamoto, Junji, Seki, Shuhji, Miura, Soichiro, Hokari, Ryota
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt AKT protein Animal models Apoptosis Autocrine signalling Bile Carbon tetrachloride Cell activation Chitinase chitinase 3‐like 1 Choline Fas Fibrosis Glycosyl hydrolase Hydrolase Liver Liver diseases liver fibrosis macrophage Macrophages Methionine Nutrient deficiency Original Pathophysiology Serum levels Therapeutic applications
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