LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma

The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several in - vivo and in - vitro studies were performed. Potential mechan...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.19139-12, Article 19139
Hauptverfasser:	Yang, Yuhua, Xu, Wenxian, Zheng, Zhuojun, Cao, Zhihai
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 45/61 692/4028/67/1813/1634 692/53/2422 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Argonaute 2 protein Base Sequence Bioinformatics Biomarkers Cell Line, Tumor Cell lines Cell proliferation Cell Proliferation - genetics Cell Survival - genetics Disease-Free Survival DNA microarrays Down-Regulation - genetics Female Fluorescence in situ hybridization Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Male Melanoma Melanoma - genetics Melanoma - pathology Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged multidisciplinary Multivariate Analysis Neoplasm Invasiveness Non-coding RNA Reproducibility of Results RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Science
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