LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma
The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several in - vivo and in - vitro studies were performed. Potential mechan...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2019-12, Vol.9 (1), p.19139-12, Article 19139 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 1 |
| container_start_page | 19139 |
| container_title | Scientific reports |
| container_volume | 9 |
| creator | Yang, Yuhua Xu, Wenxian Zheng, Zhuojun Cao, Zhihai |
| description | The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several
in
-
vivo
and
in
-
vitro
studies were performed. Potential mechanisms of competitive endogenous RNAs (ceRNAs) were predicted by using bioinformatics analysis and explored by western blot assay, fluorescence
in situ
hybridization assay, real-time quantitative PCR (RT-qPCR) array, RNA pull-down analysis, AGO2-RIP assay, and dual-luciferase reporter assay. The results demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the
in-vitro
and
in-vivo
experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. Bioinformatics analyses suggested that miR-218 could be a direct target of LINC00459. In addition, miR-218 was proved to be able to directly target the dickkopf-related protein 3 (DKK3) gene. In conclusion, our analysis suggested that the LINC00459 could sponge miR-218 and increase the expression of DKK3 gene, thus inhibiting the invasion and proliferation of melanoma cells, which indicated that the LINC00459 could be an effective biomarker for melanoma and its potential as the therapeutic target. |
| doi_str_mv | 10.1038/s41598-019-55701-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6914790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2327346148</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-e5fb7ed017700f9d579aeb8f4eb67b4aee5c07d5661619ed2a4dd03a2cb4caf23</originalsourceid><addsrcrecordid>eNp9kc1OGzEUha2qqEGUF-iistRNN0P9Ox5vKqEAJSICCdFNN5Zn5k5iNGMHexLB29chlAILvLGt-91zfXwQ-kLJESW8-pEElboqCNWFlIrQ4v4D2mdEyIJxxj6-OE_QYUq3JC_JtKD6E5pwWglBGd1Hf-azyynJqMZpFfzC-QUe3HXBaIXHgKGHjR0Bn1xccOz80tVuTHgVQ-86iHZ0wWPr21za2LS9OI8H6K0Pg_2M9jrbJzh82g_Q77PTm-l5Mb_6NZsez4tGEjYWILtaQUuoUoR0upVKW6irTkBdqlpYANkQ1cqypCXV0DIr2pZwy5paNLZj_AD93Omu1vUAbQN-jLY3q-gGGx9MsM68rni3NIuwMaWmQmmSBb4_CcRwt4Y0msGlBvpsA8I6mfyJSnOphM7otzfobVhHn-0ZJrXkRHIh36WyFhclFVWm2I5qYkgpQvf8ZErMNmOzy9jkjM1jxuY-N319afa55V-iGeA7IOWSX0D8P_sd2b9S7rEW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2327346148</pqid></control><display><type>article</type><title>LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Yang, Yuhua ; Xu, Wenxian ; Zheng, Zhuojun ; Cao, Zhihai</creator><creatorcontrib>Yang, Yuhua ; Xu, Wenxian ; Zheng, Zhuojun ; Cao, Zhihai</creatorcontrib><description>The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several
in
-
vivo
and
in
-
vitro
studies were performed. Potential mechanisms of competitive endogenous RNAs (ceRNAs) were predicted by using bioinformatics analysis and explored by western blot assay, fluorescence
in situ
hybridization assay, real-time quantitative PCR (RT-qPCR) array, RNA pull-down analysis, AGO2-RIP assay, and dual-luciferase reporter assay. The results demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the
in-vitro
and
in-vivo
experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. Bioinformatics analyses suggested that miR-218 could be a direct target of LINC00459. In addition, miR-218 was proved to be able to directly target the dickkopf-related protein 3 (DKK3) gene. In conclusion, our analysis suggested that the LINC00459 could sponge miR-218 and increase the expression of DKK3 gene, thus inhibiting the invasion and proliferation of melanoma cells, which indicated that the LINC00459 could be an effective biomarker for melanoma and its potential as the therapeutic target.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-55701-x</identifier><identifier>PMID: 31844121</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/109 ; 13/2 ; 13/31 ; 45/61 ; 692/4028/67/1813/1634 ; 692/53/2422 ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Argonaute 2 protein ; Base Sequence ; Bioinformatics ; Biomarkers ; Cell Line, Tumor ; Cell lines ; Cell proliferation ; Cell Proliferation - genetics ; Cell Survival - genetics ; Disease-Free Survival ; DNA microarrays ; Down-Regulation - genetics ; Female ; Fluorescence in situ hybridization ; Gene Expression Regulation, Neoplastic ; Humanities and Social Sciences ; Humans ; Male ; Melanoma ; Melanoma - genetics ; Melanoma - pathology ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; multidisciplinary ; Multivariate Analysis ; Neoplasm Invasiveness ; Non-coding RNA ; Reproducibility of Results ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Science</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.19139-12, Article 19139</ispartof><rights>The Author(s) 2019. corrected publication 2021</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. corrected publication 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019, corrected publication 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-e5fb7ed017700f9d579aeb8f4eb67b4aee5c07d5661619ed2a4dd03a2cb4caf23</citedby><cites>FETCH-LOGICAL-c502t-e5fb7ed017700f9d579aeb8f4eb67b4aee5c07d5661619ed2a4dd03a2cb4caf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914790/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914790/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31844121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yuhua</creatorcontrib><creatorcontrib>Xu, Wenxian</creatorcontrib><creatorcontrib>Zheng, Zhuojun</creatorcontrib><creatorcontrib>Cao, Zhihai</creatorcontrib><title>LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several
in
-
vivo
and
in
-
vitro
studies were performed. Potential mechanisms of competitive endogenous RNAs (ceRNAs) were predicted by using bioinformatics analysis and explored by western blot assay, fluorescence
in situ
hybridization assay, real-time quantitative PCR (RT-qPCR) array, RNA pull-down analysis, AGO2-RIP assay, and dual-luciferase reporter assay. The results demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the
in-vitro
and
in-vivo
experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. Bioinformatics analyses suggested that miR-218 could be a direct target of LINC00459. In addition, miR-218 was proved to be able to directly target the dickkopf-related protein 3 (DKK3) gene. In conclusion, our analysis suggested that the LINC00459 could sponge miR-218 and increase the expression of DKK3 gene, thus inhibiting the invasion and proliferation of melanoma cells, which indicated that the LINC00459 could be an effective biomarker for melanoma and its potential as the therapeutic target.</description><subject>13/109</subject><subject>13/2</subject><subject>13/31</subject><subject>45/61</subject><subject>692/4028/67/1813/1634</subject><subject>692/53/2422</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Argonaute 2 protein</subject><subject>Base Sequence</subject><subject>Bioinformatics</subject><subject>Biomarkers</subject><subject>Cell Line, Tumor</subject><subject>Cell lines</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Cell Survival - genetics</subject><subject>Disease-Free Survival</subject><subject>DNA microarrays</subject><subject>Down-Regulation - genetics</subject><subject>Female</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma - genetics</subject><subject>Melanoma - pathology</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Non-coding RNA</subject><subject>Reproducibility of Results</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Science</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1OGzEUha2qqEGUF-iistRNN0P9Ox5vKqEAJSICCdFNN5Zn5k5iNGMHexLB29chlAILvLGt-91zfXwQ-kLJESW8-pEElboqCNWFlIrQ4v4D2mdEyIJxxj6-OE_QYUq3JC_JtKD6E5pwWglBGd1Hf-azyynJqMZpFfzC-QUe3HXBaIXHgKGHjR0Bn1xccOz80tVuTHgVQ-86iHZ0wWPr21za2LS9OI8H6K0Pg_2M9jrbJzh82g_Q77PTm-l5Mb_6NZsez4tGEjYWILtaQUuoUoR0upVKW6irTkBdqlpYANkQ1cqypCXV0DIr2pZwy5paNLZj_AD93Omu1vUAbQN-jLY3q-gGGx9MsM68rni3NIuwMaWmQmmSBb4_CcRwt4Y0msGlBvpsA8I6mfyJSnOphM7otzfobVhHn-0ZJrXkRHIh36WyFhclFVWm2I5qYkgpQvf8ZErMNmOzy9jkjM1jxuY-N319afa55V-iGeA7IOWSX0D8P_sd2b9S7rEW</recordid><startdate>20191216</startdate><enddate>20191216</enddate><creator>Yang, Yuhua</creator><creator>Xu, Wenxian</creator><creator>Zheng, Zhuojun</creator><creator>Cao, Zhihai</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191216</creationdate><title>LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma</title><author>Yang, Yuhua ; Xu, Wenxian ; Zheng, Zhuojun ; Cao, Zhihai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-e5fb7ed017700f9d579aeb8f4eb67b4aee5c07d5661619ed2a4dd03a2cb4caf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>13/109</topic><topic>13/2</topic><topic>13/31</topic><topic>45/61</topic><topic>692/4028/67/1813/1634</topic><topic>692/53/2422</topic><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Animals</topic><topic>Argonaute 2 protein</topic><topic>Base Sequence</topic><topic>Bioinformatics</topic><topic>Biomarkers</topic><topic>Cell Line, Tumor</topic><topic>Cell lines</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>Cell Survival - genetics</topic><topic>Disease-Free Survival</topic><topic>DNA microarrays</topic><topic>Down-Regulation - genetics</topic><topic>Female</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma</topic><topic>Melanoma - genetics</topic><topic>Melanoma - pathology</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Non-coding RNA</topic><topic>Reproducibility of Results</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yuhua</creatorcontrib><creatorcontrib>Xu, Wenxian</creatorcontrib><creatorcontrib>Zheng, Zhuojun</creatorcontrib><creatorcontrib>Cao, Zhihai</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yuhua</au><au>Xu, Wenxian</au><au>Zheng, Zhuojun</au><au>Cao, Zhihai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-16</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>19139</spage><epage>12</epage><pages>19139-12</pages><artnum>19139</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several
in
-
vivo
and
in
-
vitro
studies were performed. Potential mechanisms of competitive endogenous RNAs (ceRNAs) were predicted by using bioinformatics analysis and explored by western blot assay, fluorescence
in situ
hybridization assay, real-time quantitative PCR (RT-qPCR) array, RNA pull-down analysis, AGO2-RIP assay, and dual-luciferase reporter assay. The results demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the
in-vitro
and
in-vivo
experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. Bioinformatics analyses suggested that miR-218 could be a direct target of LINC00459. In addition, miR-218 was proved to be able to directly target the dickkopf-related protein 3 (DKK3) gene. In conclusion, our analysis suggested that the LINC00459 could sponge miR-218 and increase the expression of DKK3 gene, thus inhibiting the invasion and proliferation of melanoma cells, which indicated that the LINC00459 could be an effective biomarker for melanoma and its potential as the therapeutic target.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31844121</pmid><doi>10.1038/s41598-019-55701-x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2019-12, Vol.9 (1), p.19139-12, Article 19139 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6914790 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 13/109 13/2 13/31 45/61 692/4028/67/1813/1634 692/53/2422 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Argonaute 2 protein Base Sequence Bioinformatics Biomarkers Cell Line, Tumor Cell lines Cell proliferation Cell Proliferation - genetics Cell Survival - genetics Disease-Free Survival DNA microarrays Down-Regulation - genetics Female Fluorescence in situ hybridization Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Male Melanoma Melanoma - genetics Melanoma - pathology Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged multidisciplinary Multivariate Analysis Neoplasm Invasiveness Non-coding RNA Reproducibility of Results RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Science |
| title | LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T12%3A01%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LINC00459%20sponging%20miR-218%20to%20elevate%20DKK3%20inhibits%20proliferation%20and%20invasion%20in%20melanoma&rft.jtitle=Scientific%20reports&rft.au=Yang,%20Yuhua&rft.date=2019-12-16&rft.volume=9&rft.issue=1&rft.spage=19139&rft.epage=12&rft.pages=19139-12&rft.artnum=19139&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-019-55701-x&rft_dat=%3Cproquest_pubme%3E2327346148%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2327346148&rft_id=info:pmid/31844121&rfr_iscdi=true |