Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures

[Display omitted] •Genistein inhibits proliferation in the neonatal mouse pituitary.•Genistein induces the cell cycle inhibitor CDKN1A in the neonatal pituitary.•Genistein triggers cellular senescence in the neonatal pituitary. Genistein is an isoflavone abundant in soybean and infants are exposed t...

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Veröffentlicht in:	Toxicology (Amsterdam) 2019-11, Vol.427, p.152306-152306, Article 152306
Hauptverfasser:	Weis, Karen E., Raetzman, Lori T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn apoptosis beta-galactosidase cell cycle Cell Cycle Proteins - genetics Cell Proliferation - drug effects cell senescence Cellular Senescence - drug effects cyclins enzyme inhibitors estradiol estrogen receptors Female gene expression gene expression regulation genes Genistein Genistein - pharmacology infants Ki-67 Antigen - genetics Male messenger RNA Mice neonatal development Pituitary pituitary gland Pituitary Gland - drug effects Pituitary Gland - metabolism postpartum period Proliferation Proto-Oncogene Proteins c-bcl-2 - genetics Receptor, Cholecystokinin A - genetics Senescence soybeans staining
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