The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

Extracellular DNA (eDNA) is a critical component of the extracellular matrix of bacterial biofilms that protects the resident bacteria from environmental hazards, which includes imparting significantly greater resistance to antibiotics and host immune effectors. eDNA is organized into a lattice-like...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-12, Vol.116 (50), p.25068-25077
Hauptverfasser:	Devaraj, Aishwarya, Buzzo, John R., Mashburn-Warren, Lauren, Gloag, Erin S., Novotny, Laura A., Stoodley, Paul, Bakaletz, Lauren O., Goodman, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacteria Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biofilms Biological Sciences Chinchilla Critical components Cystic fibrosis Deoxyribonucleic acid Disease Models, Animal Disruption DNA DNA Helicases DNA, Cruciform - chemistry DNA, Cruciform - metabolism DNA-binding protein DNA-Binding Proteins E coli Environmental DNA Environmental hazards Escherichia coli Proteins Extracellular matrix Extracellular Matrix - chemistry Extracellular Matrix - metabolism Holliday Junction Resolvases - chemistry Holliday Junction Resolvases - metabolism Holliday junctions Intermediates Mechanical properties Middle ear Otitis Media PNAS Plus Proteins Recombination Recombination, Genetic Resolvase Sputum Structural integrity
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