Differential cardiovascular responses to cutaneous afferent subtypes in a nociceptive intersegmental spinal reflex
Electrical stimulation to segmental dorsal cutaneous nerves (DCNs) activates a nociceptive sensorimotor reflex and the same afferent stimulation also evokes blood pressure (BP) and heart rate (HR) responses in rats. To investigate the relationship between those cardiovascular responses and the activ...
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| Veröffentlicht in: | Scientific reports 2019-12, Vol.9 (1), p.19049-14, Article 19049 |
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| description | Electrical stimulation to segmental dorsal cutaneous nerves (DCNs) activates a nociceptive sensorimotor reflex and the same afferent stimulation also evokes blood pressure (BP) and heart rate (HR) responses in rats. To investigate the relationship between those cardiovascular responses and the activation of nociceptive afferents, we analyzed BP and HR responses to electrical stimulations at each DCN from T6 to L1 at 0.5 mA to activate A-fiber alone or 5 mA to activate both A- and C-fibers at different frequencies. Evoked cardiovascular responses showed a decrease and then an increase in BP and an increase and then a plateau in HR. Segmentally, both cardiovascular responses tended to be larger when evoked from the more rostral DCNs. Stimulation frequency had a larger effect on cardiovascular responses than the rostrocaudal level of the DCN input. Stimulation strength showed a large effect on BP changes dependent on C-fibers whereas HR changes were dependent on A-fibers. Additional A-fiber activation by stimulating up to 4 adjacent DCNs concurrently, but only at 0.5 mA, affected HR but not BP. These data support that cutaneous nociceptive afferent subtypes preferentially contribute to different cardiovascular responses, A-fibers to HR and C-fibers to BP, with temporal (stimulation frequency) and spatial (rostrocaudal level) dynamics. |
| doi_str_mv | 10.1038/s41598-019-54072-7 |
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To investigate the relationship between those cardiovascular responses and the activation of nociceptive afferents, we analyzed BP and HR responses to electrical stimulations at each DCN from T6 to L1 at 0.5 mA to activate A-fiber alone or 5 mA to activate both A- and C-fibers at different frequencies. Evoked cardiovascular responses showed a decrease and then an increase in BP and an increase and then a plateau in HR. Segmentally, both cardiovascular responses tended to be larger when evoked from the more rostral DCNs. Stimulation frequency had a larger effect on cardiovascular responses than the rostrocaudal level of the DCN input. Stimulation strength showed a large effect on BP changes dependent on C-fibers whereas HR changes were dependent on A-fibers. Additional A-fiber activation by stimulating up to 4 adjacent DCNs concurrently, but only at 0.5 mA, affected HR but not BP. These data support that cutaneous nociceptive afferent subtypes preferentially contribute to different cardiovascular responses, A-fibers to HR and C-fibers to BP, with temporal (stimulation frequency) and spatial (rostrocaudal level) dynamics.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-54072-7</identifier><identifier>PMID: 31836817</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/3917 ; 631/443/376 ; Animals ; Blood pressure ; Blood Pressure - physiology ; Cardiovascular system ; Cardiovascular System - metabolism ; Electric Stimulation ; Female ; Heart rate ; Heart Rate - physiology ; Humanities and Social Sciences ; multidisciplinary ; Muscles - physiology ; Nerve Fibers, Myelinated - physiology ; Nervous system ; Neurosciences ; Nociception - physiology ; Pain perception ; Rats, Long-Evans ; Reflex - physiology ; Science ; Science (multidisciplinary) ; Sensory neurons ; Skin - innervation ; Spinal Cord - physiology ; Spinal cord injuries</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.19049-14, Article 19049</ispartof><rights>The Author(s) 2019</rights><rights>2019. 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To investigate the relationship between those cardiovascular responses and the activation of nociceptive afferents, we analyzed BP and HR responses to electrical stimulations at each DCN from T6 to L1 at 0.5 mA to activate A-fiber alone or 5 mA to activate both A- and C-fibers at different frequencies. Evoked cardiovascular responses showed a decrease and then an increase in BP and an increase and then a plateau in HR. Segmentally, both cardiovascular responses tended to be larger when evoked from the more rostral DCNs. Stimulation frequency had a larger effect on cardiovascular responses than the rostrocaudal level of the DCN input. Stimulation strength showed a large effect on BP changes dependent on C-fibers whereas HR changes were dependent on A-fibers. Additional A-fiber activation by stimulating up to 4 adjacent DCNs concurrently, but only at 0.5 mA, affected HR but not BP. These data support that cutaneous nociceptive afferent subtypes preferentially contribute to different cardiovascular responses, A-fibers to HR and C-fibers to BP, with temporal (stimulation frequency) and spatial (rostrocaudal level) dynamics.</description><subject>631/378/3917</subject><subject>631/443/376</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular system</subject><subject>Cardiovascular System - metabolism</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Muscles - physiology</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nervous system</subject><subject>Neurosciences</subject><subject>Nociception - physiology</subject><subject>Pain perception</subject><subject>Rats, Long-Evans</subject><subject>Reflex - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hyun Joon</au><au>White, Jason M.</au><au>Chung, Jumi</au><au>Malone, Patrick</au><au>DeWeerth, Stephen P.</au><au>Tansey, Keith E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential cardiovascular responses to cutaneous afferent subtypes in a nociceptive intersegmental spinal reflex</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-13</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>19049</spage><epage>14</epage><pages>19049-14</pages><artnum>19049</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Electrical stimulation to segmental dorsal cutaneous nerves (DCNs) activates a nociceptive sensorimotor reflex and the same afferent stimulation also evokes blood pressure (BP) and heart rate (HR) responses in rats. To investigate the relationship between those cardiovascular responses and the activation of nociceptive afferents, we analyzed BP and HR responses to electrical stimulations at each DCN from T6 to L1 at 0.5 mA to activate A-fiber alone or 5 mA to activate both A- and C-fibers at different frequencies. Evoked cardiovascular responses showed a decrease and then an increase in BP and an increase and then a plateau in HR. Segmentally, both cardiovascular responses tended to be larger when evoked from the more rostral DCNs. Stimulation frequency had a larger effect on cardiovascular responses than the rostrocaudal level of the DCN input. Stimulation strength showed a large effect on BP changes dependent on C-fibers whereas HR changes were dependent on A-fibers. Additional A-fiber activation by stimulating up to 4 adjacent DCNs concurrently, but only at 0.5 mA, affected HR but not BP. These data support that cutaneous nociceptive afferent subtypes preferentially contribute to different cardiovascular responses, A-fibers to HR and C-fibers to BP, with temporal (stimulation frequency) and spatial (rostrocaudal level) dynamics.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31836817</pmid><doi>10.1038/s41598-019-54072-7</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-6985-0690</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/3917 631/443/376 Animals Blood pressure Blood Pressure - physiology Cardiovascular system Cardiovascular System - metabolism Electric Stimulation Female Heart rate Heart Rate - physiology Humanities and Social Sciences multidisciplinary Muscles - physiology Nerve Fibers, Myelinated - physiology Nervous system Neurosciences Nociception - physiology Pain perception Rats, Long-Evans Reflex - physiology Science Science (multidisciplinary) Sensory neurons Skin - innervation Spinal Cord - physiology Spinal cord injuries |
| title | Differential cardiovascular responses to cutaneous afferent subtypes in a nociceptive intersegmental spinal reflex |
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