Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease

Dengue virus (DENV) infection causes serious health problems in humans for which no drug is currently available. Recently, DENV NS2B-NS3 protease has been proposed as a primary target for anti-dengue drug discovery due to its important role in new virus particle formation by conducting DENV polyprot...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.19059-12, Article 19059
Hauptverfasser:	Bharadwaj, Shiv, Lee, Kyung Eun, Dwivedi, Vivek Dhar, Yadava, Umesh, Panwar, Aleksha, Lucas, Stuart. J., Pandey, Amit, Kang, Sang Gu
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 631/114/2411 631/326/2522 Amino Acid Sequence Antifungal agents Antiviral Agents - pharmacology Bioactive compounds Dengue fever Dengue virus Dengue Virus - drug effects Dengue Virus - physiology Drug Discovery Drug Evaluation, Preclinical Ganoderma lucidum Health problems Humanities and Social Sciences Molecular Docking Simulation Molecular Dynamics Simulation multidisciplinary Mushrooms Proteinase inhibitors Reishi - chemistry Science Science (multidisciplinary) Serine Endopeptidases - chemistry Serine Endopeptidases - metabolism Thermodynamics Triterpenes - pharmacology Triterpenoids Vector-borne diseases Viral infections Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism
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