Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation

Abstract Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory...

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Veröffentlicht in:	The Journal of infectious diseases 2020-01, Vol.221 (1), p.138-145
Hauptverfasser:	Attaher, Oumar, Zaidi, Irfan, Kwan, Jennifer L, Issiaka, Djibrilla, Samassekou, Mamoudou B, Cisse, Kadidia B, Coulibaly, Barou, Keita, Sekouba, Sissoko, Sibiri, Traore, Tiangoua, Diarra, Kalifa, Diarra, Bacary S, Dembele, Adama, Kanoute, Moussa B, Mahamar, Almahamoudou, Barry, Amadou, Fried, Michal, Dicko, Alassane, Duffy, Patrick E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amodiaquine - therapeutic use Antigens, CD - blood Antimalarials - therapeutic use Biomarkers - blood CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD8 antigen Child, Preschool Children Clinical trials Drug Combinations Female Flow cytometry Forkhead Transcription Factors - blood Foxp3 protein Humans Immune system Immunoregulation Infant Lymphocytes Lymphocytes T Major and Brief Reports Malaria Malaria, Falciparum - immunology Malaria, Falciparum - prevention & control Male PD-1 protein Plasmodium falciparum Programmed Cell Death 1 Receptor - blood Pyrimethamine - therapeutic use Seasons Sulfadoxine - therapeutic use T-Lymphocytes, Regulatory
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