STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer

Abstract Background Radioresistance represents a major problem in the treatment of head and neck cancer (HNC) patients. To improve response, understanding tumor microenvironmental factors that contribute to radiation resistance is important. Regulatory T cells (Tregs) are enriched in numerous cancer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2019-12, Vol.111 (12), p.1339-1349
Hauptverfasser:	Oweida, Ayman J, Darragh, Laurel, Phan, Andy, Binder, David, Bhatia, Shilpa, Mueller, Adam, Court, Benjamin Van, Milner, Dallin, Raben, David, Woessner, Richard, Heasley, Lynn, Nemenoff, Raphael, Clambey, Eric, Karam, Sana D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antisense oligonucleotides Cancer Cancer therapies CD25 antigen CD4 antigen CD8 antigen Clinical trials CTLA-4 protein Cytotoxicity Depletion Effector cells Enzyme-linked immunosorbent assay Flow cytometry Head & neck cancer Immune system Immunological memory Immunomodulation Immunoregulation Lymphocytes Lymphocytes T Macrophages Microenvironments Modulation Patients PD-L1 protein Radiation Radiation therapy Radiation tolerance Radioresistance Stat3 protein Statistical analysis Statistical tests Suppressor cells Toxicity Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!