TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1

The response of eosinophils (Eos) to respiratory virus has emerged as an important link between pulmonary infection and allergic asthmatic exacerbations. Eos activate innate immune responses through TLR signaling. In this study, using mouse and human Eos and mice lacking the prolyl isomerase Pin1 se...

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Veröffentlicht in:The Journal of immunology (1950) 2018-12, Vol.201 (12), p.3503-3513
Hauptverfasser: Shen, Zhong-Jian, Hu, Jie, Kashi, Venkatesh, Bochkov, Yury A, Gern, James E, Malter, James S
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Sprache:eng
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