Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Several pharmacological, dietary, and genetic interventions that increase mammalian lifespan are known, but general principles of lifespan extension remain unclear. Here, we performed RNA sequencing (RNA-seq) analyses of mice subjected to 8 longevity interventions. We discovered a feminizing effect...

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Veröffentlicht in:	Cell metabolism 2019-09, Vol.30 (3), p.573-593.e8
Hauptverfasser:	Tyshkovskiy, Alexander, Bozaykut, Perinur, Borodinova, Anastasia A., Gerashchenko, Maxim V., Ables, Gene P., Garratt, Michael, Khaitovich, Philipp, Clish, Clary B., Miller, Richard A., Gladyshev, Vadim N.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging caloric restriction feminizing effect gene expression GENtervention growth hormone lifespan extension lifespan-extending interventions longevity longevity signatures rapamycin
Online-Zugang:	Volltext
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