Organoids from the Human Fetal and Adult Pancreas
Purpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. Re...
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| Veröffentlicht in: | Current diabetes reports 2019-12, Vol.19 (12), p.160-10, Article 160 |
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| creator | Balak, Jeetindra R. A. Juksar, Juri Carlotti, Françoise Lo Nigro, Antonio de Koning, Eelco J. P. |
| description | Purpose of Review
Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.
Recent Findings
Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.
Summary
Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening. |
| doi_str_mv | 10.1007/s11892-019-1261-z |
| format | Article |
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Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.
Recent Findings
Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.
Summary
Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.</description><identifier>ISSN: 1534-4827</identifier><identifier>EISSN: 1539-0829</identifier><identifier>DOI: 10.1007/s11892-019-1261-z</identifier><identifier>PMID: 31828551</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biology ; Cancer ; Diabetes ; Disease ; Extracellular matrix ; Glucagon ; Growth factors ; Immunology ; Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors) ; Medicine ; Medicine & Public Health ; Morphogenesis ; Pancreas ; Pancreatic cancer ; Regenerative Medicine ; Regenerative Medicine (L Piemonti and V Sordi ; Section Editors ; Stem cells ; Topical Collection on Immunology ; Transplantation</subject><ispartof>Current diabetes reports, 2019-12, Vol.19 (12), p.160-10, Article 160</ispartof><rights>The Author(s) 2019</rights><rights>Current Diabetes Reports is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under SubType="CC BY" Type="OpenAccess" Version="4.0"> Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-9c6834d4f4a4a78c8dadabe033b42fec519b99451043d5e51243d64a79a204de3</citedby><cites>FETCH-LOGICAL-c536t-9c6834d4f4a4a78c8dadabe033b42fec519b99451043d5e51243d64a79a204de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11892-019-1261-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11892-019-1261-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31828551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balak, Jeetindra R. A.</creatorcontrib><creatorcontrib>Juksar, Juri</creatorcontrib><creatorcontrib>Carlotti, Françoise</creatorcontrib><creatorcontrib>Lo Nigro, Antonio</creatorcontrib><creatorcontrib>de Koning, Eelco J. P.</creatorcontrib><title>Organoids from the Human Fetal and Adult Pancreas</title><title>Current diabetes reports</title><addtitle>Curr Diab Rep</addtitle><addtitle>Curr Diab Rep</addtitle><description>Purpose of Review
Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.
Recent Findings
Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.
Summary
Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.</description><subject>Biology</subject><subject>Cancer</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Extracellular matrix</subject><subject>Glucagon</subject><subject>Growth factors</subject><subject>Immunology</subject><subject>Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphogenesis</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Regenerative Medicine</subject><subject>Regenerative Medicine (L Piemonti and V Sordi</subject><subject>Section Editors</subject><subject>Stem cells</subject><subject>Topical Collection on Immunology</subject><subject>Transplantation</subject><issn>1534-4827</issn><issn>1539-0829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1Lw0AQhhdRbK3-AC8S8OIlurMfafYilGKtINSDnpdtdtOmJJu6mwj217uxtX6ApxmY531nhhehc8DXgPHwxgOkgsQYRAwkgXhzgPrAqYhxSsThZ89ilpJhD514v8KYBBU_Rj0KKUk5hz6CmVsoWxfaR7mrq6hZmmjaVspGE9OoMlJWRyPdlk30pGzmjPKn6ChXpTdnuzpAL5O75_E0fpzdP4xHj3HGadLEIktSyjTLmWJqmGapVlrNDaZ0zkhuMg5iLgTjgBnV3HAgoSYBFYpgpg0doNut77qdV0ZnxjZOlXLtikq5d1mrQv6e2GIpF_WbTAROCCTB4Gpn4OrX1vhGVoXPTFkqa-rWS0IJJ0Jw3KGXf9BV3Tob3usoNhSEgggUbKnM1d47k--PASy7QOQ2EBkCkV0gchM0Fz-_2Cu-EggA2QI-jOzCuO_V_7t-AOSNlVc</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Balak, Jeetindra R. A.</creator><creator>Juksar, Juri</creator><creator>Carlotti, Françoise</creator><creator>Lo Nigro, Antonio</creator><creator>de Koning, Eelco J. P.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191201</creationdate><title>Organoids from the Human Fetal and Adult Pancreas</title><author>Balak, Jeetindra R. A. ; Juksar, Juri ; Carlotti, Françoise ; Lo Nigro, Antonio ; de Koning, Eelco J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-9c6834d4f4a4a78c8dadabe033b42fec519b99451043d5e51243d64a79a204de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biology</topic><topic>Cancer</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Extracellular matrix</topic><topic>Glucagon</topic><topic>Growth factors</topic><topic>Immunology</topic><topic>Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphogenesis</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Regenerative Medicine</topic><topic>Regenerative Medicine (L Piemonti and V Sordi</topic><topic>Section Editors</topic><topic>Stem cells</topic><topic>Topical Collection on Immunology</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balak, Jeetindra R. A.</creatorcontrib><creatorcontrib>Juksar, Juri</creatorcontrib><creatorcontrib>Carlotti, Françoise</creatorcontrib><creatorcontrib>Lo Nigro, Antonio</creatorcontrib><creatorcontrib>de Koning, Eelco J. 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A.</au><au>Juksar, Juri</au><au>Carlotti, Françoise</au><au>Lo Nigro, Antonio</au><au>de Koning, Eelco J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organoids from the Human Fetal and Adult Pancreas</atitle><jtitle>Current diabetes reports</jtitle><stitle>Curr Diab Rep</stitle><addtitle>Curr Diab Rep</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>19</volume><issue>12</issue><spage>160</spage><epage>10</epage><pages>160-10</pages><artnum>160</artnum><issn>1534-4827</issn><eissn>1539-0829</eissn><abstract>Purpose of Review
Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.
Recent Findings
Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.
Summary
Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31828551</pmid><doi>10.1007/s11892-019-1261-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biology Cancer Diabetes Disease Extracellular matrix Glucagon Growth factors Immunology Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors) Medicine Medicine & Public Health Morphogenesis Pancreas Pancreatic cancer Regenerative Medicine Regenerative Medicine (L Piemonti and V Sordi Section Editors Stem cells Topical Collection on Immunology Transplantation |
| title | Organoids from the Human Fetal and Adult Pancreas |
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