Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112

Summary Mycobacterium tuberculosis (Mtb) is able to persist in the body through months of multi‐drug therapy. Mycobacteria possess a wide range of regulatory proteins, including the protein kinase B (PknB) which controls peptidoglycan biosynthesis during growth. Here, we observed that depletion of P...

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Veröffentlicht in:	Molecular microbiology 2019-12, Vol.112 (6), p.1847-1862
Hauptverfasser:	Alqaseer, Kawther, Turapov, Obolbek, Barthe, Philippe, Jagatia, Heena, De Visch, Angélique, Roumestand, Christian, Wegrzyn, Malgorzata, Bartek, Iona L., Voskuil, Martin I., O'Hare, Helen M., Ajuh, Paul, Bottrill, Andrew R., Witney, Adam A., Cohen‐Gonsaud, Martin, Waddell, Simon J., Mukamolova, Galina V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation AKT protein Anisotropy Bacteriology Binding Biochemistry, Molecular Biology Biosynthesis Chemotherapy Deoxyribonucleic acid Depletion DNA DNA sequencing Drug therapy Electrophoretic mobility Fluorescence Genomics Hypoxia Kinases Life Sciences Microbiology and Parasitology Mycobacterium tuberculosis NMR Nuclear magnetic resonance Nucleotide sequence Peptidoglycans Phosphorylation Proteins Regulatory proteins Threonine Transcription Tuberculosis
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