Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification

•The interactions of C. neoformans biofilm-derived cells with macrophages were evaluated.•Biofilm-derived cryptococci are more difficult to phagocytize and killed by macrophages.•Increased capsule size and polysaccharide released was evinced in fungal biofilm cells.•Upregulation of capsular-related...

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