Differential long‐term regulation of TAS2R14 by structurally distinct agonists

Bitter taste receptor‐14 (TAS2R14) is a GPCR also expressed on human airway smooth muscle cells, which signals to intracellular [Ca2+], resulting in relaxation of the airway, and is a novel target for bronchodilators. Here, we examine long‐term, agonist‐promoted down‐regulation of TAS2R14 expression...

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Veröffentlicht in:	The FASEB journal 2019-11, Vol.33 (11), p.12213-12225
Hauptverfasser:	Woo, Jung A., Castaño, Maria, Goss, Ashley, Kim, Donghwa, Lewandowski, Eric M., Chen, Yu, Liggett, Stephen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	[Ca2+]i beta-Arrestins - physiology Calcium - metabolism desensitization Diphenhydramine - pharmacology down‐regulation Endosomes - physiology HEK293 Cells Humans internalization Molecular Docking Simulation Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - physiology β‐arrestin
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