Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo . The Harderian gl...
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creator | García-Macia, Marina Santos-Ledo, Adrián Caballero, Beatriz Rubio-González, Adrian de Luxán-Delgado, Beatriz Potes, Yaiza Rodríguez-González, Susana Mª. Boga, José Antonio Coto-Montes, Ana |
description | Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed
in vivo
. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle. |
doi_str_mv | 10.1038/s41598-019-54743-5 |
format | Article |
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in vivo
. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-54743-5</identifier><identifier>PMID: 31819084</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 14/19 ; 14/28 ; 14/63 ; 631/337/474/1624 ; 631/443/494 ; 631/80/39/2346 ; 631/80/39/2348 ; 82/1 ; 82/29 ; 82/80 ; Animals ; Autophagy ; Estrous Cycle ; Estrus cycle ; Female ; Harderian gland ; Harderian Gland - metabolism ; Harderian Gland - pathology ; Homeostasis ; Hormones ; Humanities and Social Sciences ; Inflammation ; Lipids - chemistry ; Lysosomes - metabolism ; Melatonin ; Melatonin - metabolism ; Mesocricetus ; Mitochondria ; Mitochondria - metabolism ; Mitophagy ; multidisciplinary ; NF-kappa B - metabolism ; NF-κB protein ; Oxidative Stress ; Phagocytosis ; Receptors, Melatonin - metabolism ; Science ; Science (multidisciplinary) ; Sequestosome-1 Protein - metabolism ; Sex Factors ; Sexual dimorphism ; Transcription factors</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.18597-11, Article 18597</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ce7372b7ff878f1f6ebc470a62068f9659f9df11b4202d87045b75e7928840cf3</citedby><cites>FETCH-LOGICAL-c474t-ce7372b7ff878f1f6ebc470a62068f9659f9df11b4202d87045b75e7928840cf3</cites><orcidid>0000-0002-6609-6258 ; 0000-0002-3908-9060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901547/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901547/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31819084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Macia, Marina</creatorcontrib><creatorcontrib>Santos-Ledo, Adrián</creatorcontrib><creatorcontrib>Caballero, Beatriz</creatorcontrib><creatorcontrib>Rubio-González, Adrian</creatorcontrib><creatorcontrib>de Luxán-Delgado, Beatriz</creatorcontrib><creatorcontrib>Potes, Yaiza</creatorcontrib><creatorcontrib>Rodríguez-González, Susana Mª.</creatorcontrib><creatorcontrib>Boga, José Antonio</creatorcontrib><creatorcontrib>Coto-Montes, Ana</creatorcontrib><title>Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed
in vivo
. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle.</description><subject>13/51</subject><subject>14/19</subject><subject>14/28</subject><subject>14/63</subject><subject>631/337/474/1624</subject><subject>631/443/494</subject><subject>631/80/39/2346</subject><subject>631/80/39/2348</subject><subject>82/1</subject><subject>82/29</subject><subject>82/80</subject><subject>Animals</subject><subject>Autophagy</subject><subject>Estrous Cycle</subject><subject>Estrus cycle</subject><subject>Female</subject><subject>Harderian gland</subject><subject>Harderian Gland - metabolism</subject><subject>Harderian Gland - pathology</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation</subject><subject>Lipids - chemistry</subject><subject>Lysosomes - metabolism</subject><subject>Melatonin</subject><subject>Melatonin - metabolism</subject><subject>Mesocricetus</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitophagy</subject><subject>multidisciplinary</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Oxidative Stress</subject><subject>Phagocytosis</subject><subject>Receptors, Melatonin - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequestosome-1 Protein - metabolism</subject><subject>Sex Factors</subject><subject>Sexual dimorphism</subject><subject>Transcription factors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9Uctu1DAUtRCIVkN_gAWyxIYFAdt52SyQqgooUiUWwNpykuuMK8ce7GSk-QM-m9tJGQoLvPGVzrmPcw4hzzl7w1kp3-aK10oWjKuirtqqLOpH5Fywqi5EKcTjB_UZucj5luGrhaq4ekrOSi65YrI6Jz-_god-dnugZpnjbmvGw2vq3W4tqQkDndwJcIHOW6DXJg2QnAl09HcM42MYj0iEPKe4ZNofeg_vqKG7OEOYnfE0wZwc7LECa3EpjZZO4M0cgwvPyBNrfIaL-39Dvn_88O3qurj58unz1eVN0aPKueihLVvRtdbKVlpuG-gQYKYRrJFWNbWyarCcd5VgYpAtmtC1NbRKSFmx3pYb8n6du1u6CYYeb0vG611yk0kHHY3TfyPBbfUY97pRjKPTOODV_YAUfywoV08u9-DRCEDhGi0vq1bWjULqy3-ot3FJAeUdWUw1DLPcELGy-hRzTmBPx3Cm77LWa9Yas9bHrHWNTS8eyji1_E4WCeVKyAiFEdKf3f8Z-ws-37bM</recordid><startdate>20191209</startdate><enddate>20191209</enddate><creator>García-Macia, Marina</creator><creator>Santos-Ledo, Adrián</creator><creator>Caballero, Beatriz</creator><creator>Rubio-González, Adrian</creator><creator>de Luxán-Delgado, Beatriz</creator><creator>Potes, Yaiza</creator><creator>Rodríguez-González, Susana Mª.</creator><creator>Boga, José Antonio</creator><creator>Coto-Montes, Ana</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6609-6258</orcidid><orcidid>https://orcid.org/0000-0002-3908-9060</orcidid></search><sort><creationdate>20191209</creationdate><title>Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin</title><author>García-Macia, Marina ; Santos-Ledo, Adrián ; Caballero, Beatriz ; Rubio-González, Adrian ; de Luxán-Delgado, Beatriz ; Potes, Yaiza ; Rodríguez-González, Susana Mª. ; Boga, José Antonio ; Coto-Montes, Ana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ce7372b7ff878f1f6ebc470a62068f9659f9df11b4202d87045b75e7928840cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>13/51</topic><topic>14/19</topic><topic>14/28</topic><topic>14/63</topic><topic>631/337/474/1624</topic><topic>631/443/494</topic><topic>631/80/39/2346</topic><topic>631/80/39/2348</topic><topic>82/1</topic><topic>82/29</topic><topic>82/80</topic><topic>Animals</topic><topic>Autophagy</topic><topic>Estrous Cycle</topic><topic>Estrus cycle</topic><topic>Female</topic><topic>Harderian gland</topic><topic>Harderian Gland - metabolism</topic><topic>Harderian Gland - pathology</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Humanities and Social Sciences</topic><topic>Inflammation</topic><topic>Lipids - chemistry</topic><topic>Lysosomes - metabolism</topic><topic>Melatonin</topic><topic>Melatonin - metabolism</topic><topic>Mesocricetus</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Mitophagy</topic><topic>multidisciplinary</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Oxidative Stress</topic><topic>Phagocytosis</topic><topic>Receptors, Melatonin - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sequestosome-1 Protein - metabolism</topic><topic>Sex Factors</topic><topic>Sexual dimorphism</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Macia, Marina</creatorcontrib><creatorcontrib>Santos-Ledo, Adrián</creatorcontrib><creatorcontrib>Caballero, Beatriz</creatorcontrib><creatorcontrib>Rubio-González, Adrian</creatorcontrib><creatorcontrib>de Luxán-Delgado, Beatriz</creatorcontrib><creatorcontrib>Potes, Yaiza</creatorcontrib><creatorcontrib>Rodríguez-González, Susana Mª.</creatorcontrib><creatorcontrib>Boga, José Antonio</creatorcontrib><creatorcontrib>Coto-Montes, Ana</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Macia, Marina</au><au>Santos-Ledo, Adrián</au><au>Caballero, Beatriz</au><au>Rubio-González, Adrian</au><au>de Luxán-Delgado, Beatriz</au><au>Potes, Yaiza</au><au>Rodríguez-González, Susana Mª.</au><au>Boga, José Antonio</au><au>Coto-Montes, Ana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-09</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>18597</spage><epage>11</epage><pages>18597-11</pages><artnum>18597</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed
in vivo
. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31819084</pmid><doi>10.1038/s41598-019-54743-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6609-6258</orcidid><orcidid>https://orcid.org/0000-0002-3908-9060</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 13/51 14/19 14/28 14/63 631/337/474/1624 631/443/494 631/80/39/2346 631/80/39/2348 82/1 82/29 82/80 Animals Autophagy Estrous Cycle Estrus cycle Female Harderian gland Harderian Gland - metabolism Harderian Gland - pathology Homeostasis Hormones Humanities and Social Sciences Inflammation Lipids - chemistry Lysosomes - metabolism Melatonin Melatonin - metabolism Mesocricetus Mitochondria Mitochondria - metabolism Mitophagy multidisciplinary NF-kappa B - metabolism NF-κB protein Oxidative Stress Phagocytosis Receptors, Melatonin - metabolism Science Science (multidisciplinary) Sequestosome-1 Protein - metabolism Sex Factors Sexual dimorphism Transcription factors |
title | Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
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