Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin

Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo . The Harderian gl...

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Veröffentlicht in:Scientific reports 2019-12, Vol.9 (1), p.18597-11, Article 18597
Hauptverfasser: García-Macia, Marina, Santos-Ledo, Adrián, Caballero, Beatriz, Rubio-González, Adrian, de Luxán-Delgado, Beatriz, Potes, Yaiza, Rodríguez-González, Susana Mª., Boga, José Antonio, Coto-Montes, Ana
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container_issue 1
container_start_page 18597
container_title Scientific reports
container_volume 9
creator García-Macia, Marina
Santos-Ledo, Adrián
Caballero, Beatriz
Rubio-González, Adrian
de Luxán-Delgado, Beatriz
Potes, Yaiza
Rodríguez-González, Susana Mª.
Boga, José Antonio
Coto-Montes, Ana
description Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo . The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle.
doi_str_mv 10.1038/s41598-019-54743-5
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subjects 13/51
14/19
14/28
14/63
631/337/474/1624
631/443/494
631/80/39/2346
631/80/39/2348
82/1
82/29
82/80
Animals
Autophagy
Estrous Cycle
Estrus cycle
Female
Harderian gland
Harderian Gland - metabolism
Harderian Gland - pathology
Homeostasis
Hormones
Humanities and Social Sciences
Inflammation
Lipids - chemistry
Lysosomes - metabolism
Melatonin
Melatonin - metabolism
Mesocricetus
Mitochondria
Mitochondria - metabolism
Mitophagy
multidisciplinary
NF-kappa B - metabolism
NF-κB protein
Oxidative Stress
Phagocytosis
Receptors, Melatonin - metabolism
Science
Science (multidisciplinary)
Sequestosome-1 Protein - metabolism
Sex Factors
Sexual dimorphism
Transcription factors
title Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
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