Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Hypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O 2 ) as the electron recipient, causes inefficient electron transfer through the electron transport chain at the mitochondria leading to accumulation of reactive oxygen species (ROS) which could create irreversible cellular d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2019-12, Vol.10 (12), p.934-16, Article 934
Hauptverfasser:	Kung-Chun Chiu, David, Pui-Wah Tse, Aki, Law, Cheuk-Ting, Ming-Jing Xu, Iris, Lee, Derek, Chen, Mengnuo, Kit-Ho Lai, Robin, Wai-Hin Yuen, Vincent, Wing-Sum Cheu, Jacinth, Wai-Hung Ho, Daniel, Wong, Chun-Ming, Zhang, Huafeng, Ng, Irene Oi-Lin, Chak-Lui Wong, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/31 13/51 14 14/28 38 631/67/2327 631/80/86/2366 Animals Antibodies Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biochemistry Biomedical and Life Sciences Biosynthesis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell Culture Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Hypoxia - genetics Chromatin Cristae Electron transfer Electron transport chain Gene expression HeLa Cells Hep G2 Cells Hepatocellular carcinoma Heterografts Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Immunology Immunoprecipitation Life Sciences Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Mitochondria Mitochondria - metabolism Molecular modelling Oxidative stress Protein Kinases - genetics Protein Kinases - metabolism PTEN-induced putative kinase Reactive oxygen species Regulatory sequences Therapeutic applications Transcription Transcriptomes Transfection Tumor Burden - genetics Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!