Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study
Matrix metalloproteinases (MMPs) 2 and 9 may play an important role in cell proliferation and dissemination of cancer. However, few studies have compared the expression of these proteins between breast cancer and fibroadenoma. A randomized, double-blind study was carried out in 66 premenopausal wome...
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| Veröffentlicht in: | Oncotarget 2019-12, Vol.10 (64), p.6879-6884 |
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| creator | Martins, Luana Mota de Melo Escorcio Dourado, Carla Solange Campos-Verdes, Larysse Maira Sampaio, Fabiane Araújo Revoredo, Camila Maria Simplício Costa-Silva, Danylo Rafhael da Conceição Barros-Oliveira, Maria de Jesus Nery Junior, Elmo do Rego-Medeiros, Lucia Maria Gebrim, Luiz Henrique Alves-Ribeiro, Francisco Adelton Rodrigues, Gilmara Péres Chagas, Diego Cipriano do Nascimento Marreiro, Dilina da Silva, Benedito Borges |
| description | Matrix metalloproteinases (MMPs) 2 and 9 may play an important role in cell proliferation and dissemination of cancer. However, few studies have compared the expression of these proteins between breast cancer and fibroadenoma.
A randomized, double-blind study was carried out in 66 premenopausal women, aged 20-49 years, who had been diagnosed with fibroadenoma or breast cancer. The patients were divided into two groups: Group A, control (fibroadenoma, n=36) and Group B, study (cancer, n=30). Immunohistochemical analysis was performed using tissue samples of fibroadenoma and breast cancer to assess MMP-2 and MMP-9 antigen expression. Cells were considered positive if exhibiting brown cytoplasmic staining. Fisher's exact test was used to compare the percentage of cases with cells expressing MMP-2 and MMP-9 in control and study groups (p < 0.05).
Light microscopy showed a higher concentration of cells with positive cytoplasmic staining for MMP-2 and MMP-9 expression in breast cancer than in fibroadenoma. The percentage of cases with cells expressing MMP-2 in the control and study groups was 41.67% and 86.11%, respectively (p < 0.0009), whereas the percentage of cases with cells expressing MMP-9 in groups A and B was 66.67% and 93.33%, respectively (p |
| doi_str_mv | 10.18632/oncotarget.27347 |
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A randomized, double-blind study was carried out in 66 premenopausal women, aged 20-49 years, who had been diagnosed with fibroadenoma or breast cancer. The patients were divided into two groups: Group A, control (fibroadenoma, n=36) and Group B, study (cancer, n=30). Immunohistochemical analysis was performed using tissue samples of fibroadenoma and breast cancer to assess MMP-2 and MMP-9 antigen expression. Cells were considered positive if exhibiting brown cytoplasmic staining. Fisher's exact test was used to compare the percentage of cases with cells expressing MMP-2 and MMP-9 in control and study groups (p < 0.05).
Light microscopy showed a higher concentration of cells with positive cytoplasmic staining for MMP-2 and MMP-9 expression in breast cancer than in fibroadenoma. The percentage of cases with cells expressing MMP-2 in the control and study groups was 41.67% and 86.11%, respectively (p < 0.0009), whereas the percentage of cases with cells expressing MMP-9 in groups A and B was 66.67% and 93.33%, respectively (p<0.0138). MMP-2 and MMP-9 positive expression was significantly higher in moderately differentiated tumors compared to well and poorly differentiated tumors, p <0.005 and p<0.001, respectively.
The current study shows that MMP-2 and MMP-9 protein expression was significantly higher in the breast cancer than in the fibroadenoma and also in moderately differentiated breast cancer.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.27347</identifier><identifier>PMID: 31839881</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2019-12, Vol.10 (64), p.6879-6884</ispartof><rights>Copyright: © 2019 Martins et al.</rights><rights>Copyright: © 2019 Martins et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3147-d56b3575114935bb9e5f1a19231c8dd2aec477921afc17aaa3f67556ab6de5853</citedby><cites>FETCH-LOGICAL-c3147-d56b3575114935bb9e5f1a19231c8dd2aec477921afc17aaa3f67556ab6de5853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31839881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martins, Luana Mota</creatorcontrib><creatorcontrib>de Melo Escorcio Dourado, Carla Solange</creatorcontrib><creatorcontrib>Campos-Verdes, Larysse Maira</creatorcontrib><creatorcontrib>Sampaio, Fabiane Araújo</creatorcontrib><creatorcontrib>Revoredo, Camila Maria Simplício</creatorcontrib><creatorcontrib>Costa-Silva, Danylo Rafhael</creatorcontrib><creatorcontrib>da Conceição Barros-Oliveira, Maria</creatorcontrib><creatorcontrib>de Jesus Nery Junior, Elmo</creatorcontrib><creatorcontrib>do Rego-Medeiros, Lucia Maria</creatorcontrib><creatorcontrib>Gebrim, Luiz Henrique</creatorcontrib><creatorcontrib>Alves-Ribeiro, Francisco Adelton</creatorcontrib><creatorcontrib>Rodrigues, Gilmara Péres</creatorcontrib><creatorcontrib>Chagas, Diego Cipriano</creatorcontrib><creatorcontrib>do Nascimento Marreiro, Dilina</creatorcontrib><creatorcontrib>da Silva, Benedito Borges</creatorcontrib><title>Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Matrix metalloproteinases (MMPs) 2 and 9 may play an important role in cell proliferation and dissemination of cancer. However, few studies have compared the expression of these proteins between breast cancer and fibroadenoma.
A randomized, double-blind study was carried out in 66 premenopausal women, aged 20-49 years, who had been diagnosed with fibroadenoma or breast cancer. The patients were divided into two groups: Group A, control (fibroadenoma, n=36) and Group B, study (cancer, n=30). Immunohistochemical analysis was performed using tissue samples of fibroadenoma and breast cancer to assess MMP-2 and MMP-9 antigen expression. Cells were considered positive if exhibiting brown cytoplasmic staining. Fisher's exact test was used to compare the percentage of cases with cells expressing MMP-2 and MMP-9 in control and study groups (p < 0.05).
Light microscopy showed a higher concentration of cells with positive cytoplasmic staining for MMP-2 and MMP-9 expression in breast cancer than in fibroadenoma. The percentage of cases with cells expressing MMP-2 in the control and study groups was 41.67% and 86.11%, respectively (p < 0.0009), whereas the percentage of cases with cells expressing MMP-9 in groups A and B was 66.67% and 93.33%, respectively (p<0.0138). MMP-2 and MMP-9 positive expression was significantly higher in moderately differentiated tumors compared to well and poorly differentiated tumors, p <0.005 and p<0.001, respectively.
The current study shows that MMP-2 and MMP-9 protein expression was significantly higher in the breast cancer than in the fibroadenoma and also in moderately differentiated breast cancer.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVUcFOHDEMjVARIOADuFQ59tChm2QymfRQqULQVkLiAufISTyQaibZJpmK7dd3WLYUfLH1_Pxs-RFyxlbnrO8E_5SiSxXyPdZzrkSr9sgR061uuJTi3av6kJyW8nO1hGxVz_UBORSsF7rv2RHZXD6uM5YSUqRpoBPUHB7phBXGMa1zqhgiFKScQvRU0xCpzQilUgfRYd7CO2QINifwGNMEnynQvPTSFP6g_0h9mu2IjR3Dwi919psTsj_AWPB0l4_J3dXl7cX35vrm24-Lr9eNE6xVjZedFVJJxlotpLUa5cCAaS6Y673ngK5VSnMGg2MKAMTQKSk7sJ1H2UtxTL48665nO6F3GGuG0axzmCBvTIJg3nZieDD36bfp9IqJli0CH3YCOf2asVQzheJwHCFimovhYnm_6rV8orJnqsuplIzDyxq2MlvXzH_XzNa1Zeb96_teJv55JP4ClpSYhw</recordid><startdate>20191203</startdate><enddate>20191203</enddate><creator>Martins, Luana Mota</creator><creator>de Melo Escorcio Dourado, Carla Solange</creator><creator>Campos-Verdes, Larysse Maira</creator><creator>Sampaio, Fabiane Araújo</creator><creator>Revoredo, Camila Maria Simplício</creator><creator>Costa-Silva, Danylo Rafhael</creator><creator>da Conceição Barros-Oliveira, Maria</creator><creator>de Jesus Nery Junior, Elmo</creator><creator>do Rego-Medeiros, Lucia Maria</creator><creator>Gebrim, Luiz Henrique</creator><creator>Alves-Ribeiro, Francisco Adelton</creator><creator>Rodrigues, Gilmara Péres</creator><creator>Chagas, Diego Cipriano</creator><creator>do Nascimento Marreiro, Dilina</creator><creator>da Silva, Benedito Borges</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191203</creationdate><title>Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study</title><author>Martins, Luana Mota ; 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However, few studies have compared the expression of these proteins between breast cancer and fibroadenoma.
A randomized, double-blind study was carried out in 66 premenopausal women, aged 20-49 years, who had been diagnosed with fibroadenoma or breast cancer. The patients were divided into two groups: Group A, control (fibroadenoma, n=36) and Group B, study (cancer, n=30). Immunohistochemical analysis was performed using tissue samples of fibroadenoma and breast cancer to assess MMP-2 and MMP-9 antigen expression. Cells were considered positive if exhibiting brown cytoplasmic staining. Fisher's exact test was used to compare the percentage of cases with cells expressing MMP-2 and MMP-9 in control and study groups (p < 0.05).
Light microscopy showed a higher concentration of cells with positive cytoplasmic staining for MMP-2 and MMP-9 expression in breast cancer than in fibroadenoma. The percentage of cases with cells expressing MMP-2 in the control and study groups was 41.67% and 86.11%, respectively (p < 0.0009), whereas the percentage of cases with cells expressing MMP-9 in groups A and B was 66.67% and 93.33%, respectively (p<0.0138). MMP-2 and MMP-9 positive expression was significantly higher in moderately differentiated tumors compared to well and poorly differentiated tumors, p <0.005 and p<0.001, respectively.
The current study shows that MMP-2 and MMP-9 protein expression was significantly higher in the breast cancer than in the fibroadenoma and also in moderately differentiated breast cancer.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>31839881</pmid><doi>10.18632/oncotarget.27347</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Research Paper |
| title | Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study |
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