Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Hydrogen-atom transfer (HAT) from a substrate carbon to an iron­(IV)-oxo (ferryl) intermediate initiates a diverse array of enzymatic transformations. For outcomes other than hydroxylation, coupling of the resultant carbon radical and hydroxo ligand (oxygen rebound) must generally be averted. A rece...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-06, Vol.141 (25), p.9964-9979
Hauptverfasser:	Dunham, Noah P, Del Río Pantoja, José M, Zhang, Bo, Rajakovich, Lauren J, Allen, Benjamin D, Krebs, Carsten, Boal, Amie K, Bollinger, J. Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystal structure Electron paramagnetic resonance spectroscopy INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Oxygen Peptides and proteins Surface interactions
Online-Zugang:	Volltext
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