Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses

Virus-like particles (VLPs) provide a well-established vaccine platform; however, the immunogenic properties acquired by VLP structure remain poorly understood. In this study, we showed that systemic vaccination with norovirus VLP recalls human IgA responses at higher magnitudes than IgG responses u...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-12, Vol.203 (12), p.3282-3292
Hauptverfasser:	Onodera, Taishi, Hashi, Kana, Shukla, Rajni Kant, Miki, Motohiro, Takai-Todaka, Reiko, Fujimoto, Akira, Kuraoka, Masayuki, Miyoshi, Tatsuya, Kobayashi, Kazuo, Hasegawa, Hideki, Ato, Manabu, Kelsoe, Garnett, Katayama, Kazuhiko, Takahashi, Yoshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Antibody Formation - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Caliciviridae Infections - prevention & control Humans Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - immunology Immunologic Memory Immunotherapy and Vaccines Mice Mice, Transgenic Norovirus - immunology Vaccines, Virus-Like Particle - immunology
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