Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits

How neural circuits develop in the human brain has remained almost impossible to study at the neuronal level. Here, we investigate human cortical neuron development, plasticity, and function using a mouse/human chimera model in which xenotransplanted human cortical pyramidal neurons integrate as sin...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2019-12, Vol.104 (5), p.972-986.e6
Hauptverfasser:	Linaro, Daniele, Vermaercke, Ben, Iwata, Ryohei, Ramaswamy, Arjun, Libé-Philippot, Baptiste, Boubakar, Leila, Davis, Brittany A., Wierda, Keimpe, Davie, Kristofer, Poovathingal, Suresh, Penttila, Pier-Andrée, Bilheu, Angéline, De Bruyne, Lore, Gall, David, Conzelmann, Karl-Klaus, Bonin, Vincent, Vanderhaeghen, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain development Brain research Cell Differentiation - physiology Circuits cortical neuron Councils dendritic spine Developmental plasticity Electrophysiology Evolution gcamp6 Heterografts human brain evolution Humans Integration Mice Microscopy multiphoton imaging Neoteny Neural networks Neurogenesis - physiology Neuroimaging Neurons Neuroplasticity pluripotent stem cell Pyramidal cells Pyramidal Cells - cytology Pyramidal Cells - physiology Pyramidal Cells - transplantation Stem cells Structure-function relationships synapse formation transplantation Transplants & implants Variance analysis Visual cortex Visual Cortex - cytology Visual Cortex - physiology Visual pathways Visual stimuli Xenografts
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