Ionizing Radiation Promotes Epithelial-to-Mesenchymal Transition in Lung Epithelial Cells by TGF-β-producing M2 Macrophages

Ionizing radiation induces pulmonary fibrosis, which is a common dose-limiting complication in patients receiving radiotherapy. Fibrosis occurs through the accumulation of large amounts of ECM components, synthesized by myofibroblasts in damaged lung tissue. Epithelial cells serve as one of the cell...

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Veröffentlicht in:	In vivo (Athens) 2019-11, Vol.33 (6), p.1773-1784
Hauptverfasser:	Park, Hae-Ran, Jo, Sung-Kee, Jung, Uhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cytokines - metabolism Epithelial Cells - metabolism Epithelial Cells - radiation effects Epithelial-Mesenchymal Transition - radiation effects Female Fibroblasts - metabolism Fibroblasts - radiation effects Lung - metabolism Lung - radiation effects Macrophages - metabolism Macrophages - radiation effects Mice Mice, Inbred C57BL Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Radiation Pneumonitis - etiology Radiation Pneumonitis - metabolism Radiation, Ionizing Signal Transduction - radiation effects Transforming Growth Factor beta - metabolism
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