Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila

Obesity is one of the most serious public health challenges in the world. Obesity during early life has been associated with an increased risk of neurodevelopmental disorders, including deficits in learning and memory, yet the underlying mechanisms remain unclear. Here, we show that early life high-...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-11, Vol.44 (12), p.2054-2064
Hauptverfasser:	Yang, Youjun, Zhong, Zhanqiong, Wang, Baojia, Xia, Xiuwen, Yao, Weiyi, Huang, Ling, Wang, Yili, Ding, Weijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Akkermansia Akkermansia muciniphila Animals Antibiotics Cognition - physiology Cognitive ability Conditioning, Classical - physiology Developmental plasticity Diet, High-Fat - adverse effects Encephalitis - microbiology Gastrointestinal Microbiome - physiology High fat diet Hippocampus Hippocampus - growth & development Hippocampus - physiopathology IL-1β Inflammation Interleukin 6 Intestinal microflora Lipopolysaccharides Long-Term Potentiation Male Memory Mice, Inbred C57BL Microbiota Neurodevelopmental disorders Neurons - physiology Obesity Obesity - microbiology Obesity - physiopathology Obesity - psychology Permeability Probiotics Public health Spatial discrimination learning Spatial Learning - physiology Spatial memory Synapses TLR4 protein Toll-Like Receptor 4 - physiology Toll-like receptors Transplantation Tumor necrosis factor-TNF Tumor necrosis factor-α Verrucomicrobia - physiology
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