Interaction of cyclosporine with phenobarbital in cats: a preliminary study

Phenobarbital (PB) decreases the cyclosporine (CsA) blood level in humans. However, the interaction of PB with CsA has not been reported in cats. This study investigated the effects of multiple doses of PB on the pharmacokinetics of CsA in three healthy cats. The treatments included oral CsA 5 mg/kg...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2019, Vol.81(11), pp.1621-1623
Hauptverfasser:	HOSHINO, Yuki, INDEN, Takanori, OTAKA, Riko, FUKUI, Daisuke, SATOH, Hiroshi, KATAYAMA, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bioavailability Biological Availability cat Cats cyclosporine Cyclosporine - pharmacokinetics Cyclosporins Dosage Dose-Response Relationship, Drug Drug Interactions Immunosuppressive agents Immunosuppressive Agents - pharmacokinetics Male Oral administration Pharmacokinetics Pharmacology Phenobarbital Phenobarbital - administration & dosage Phenobarbital - pharmacology
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