Sharp kinking of a coiled-coil in MutS allows DNA binding and release

DNA mismatch repair (MMR) corrects mismatches, small insertions and deletions in DNA during DNA replication. While scanning for mismatches, dimers of MutS embrace the DNA helix with their lever and clamp domains. Previous studies indicated generic flexibility of the lever and clamp domains of MutS p...

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Veröffentlicht in:	Nucleic acids research 2019-09, Vol.47 (16), p.8888-8898
Hauptverfasser:	Bhairosing-Kok, Doreth, Groothuizen, Flora S, Fish, Alexander, Dharadhar, Shreya, Winterwerp, Herrie H K, Sixma, Titia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism Binding Sites Cloning, Molecular Crystallography, X-Ray DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Kinetics Models, Molecular Mutagenesis, Site-Directed Mutation MutS DNA Mismatch-Binding Protein - chemistry MutS DNA Mismatch-Binding Protein - genetics MutS DNA Mismatch-Binding Protein - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Structural Biology Structure-Activity Relationship
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