Prophylactic potential of cytolethal distending toxin B (CdtB) subunit of typhoid toxin against Typhoid fever

Typhoid fever caused by Salmonella enterica serovar Typhi ( S .Typhi) continues to be a major problem, especially in developing countries. Due to the rapid emergence of multi-drug-resistant (MDR) strains, which limits the efficacy of conventional antibiotics as well as problems associated with the e...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.18404-18404, Article 18404
Hauptverfasser:	Thakur, Reena, Pathania, Preeti, Kaur, Navneet, Joshi, Vattan, Kondepudi, Kanthi Kiran, Suri, Chander Raman, Rishi, Praveen
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 631/250/590/2294 631/326/421 82 82/1 82/16 82/29 82/80 82/83 Animals Antibiotics Antibodies, Bacterial - biosynthesis Bacterial Toxins - administration & dosage Bacterial Toxins - immunology CdtB protein Cell cycle Cell lines Colony Count, Microbial Cytolethal distending toxin Deoxyribonuclease Disease Models, Animal Drug resistance Enzyme-linked immunosorbent assay Flow cytometry Gene Expression Humanities and Social Sciences Humans Immunization Immunization - methods Immunoblotting Immunogenicity Immunogenicity, Vaccine Immunoglobulin G Immunoglobulin G - biosynthesis Immunoreactivity Interleukin 10 Interleukin 6 Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Lethal dose Liver Liver - drug effects Liver - immunology Liver - microbiology Mice multidisciplinary Peritonitis Peritonitis - immunology Peritonitis - microbiology Peritonitis - mortality Peritonitis - prevention & control Proteins Salmonella typhi - drug effects Salmonella typhi - immunology Salmonella typhi - pathogenicity Science Science (multidisciplinary) Spleen Spleen - drug effects Spleen - immunology Spleen - microbiology Statistical analysis Strains (organisms) Survival Analysis Toxicity Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Typhoid Typhoid Fever - immunology Typhoid Fever - microbiology Typhoid Fever - mortality Typhoid Fever - prevention & control Typhoid-Paratyphoid Vaccines - administration & dosage Typhoid-Paratyphoid Vaccines - immunology Vaccines
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