Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential
Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus...
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| Veröffentlicht in: | Scientific reports 2019-12, Vol.9 (1), p.18452-13, Article 18452 |
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| description | Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were |
| doi_str_mv | 10.1038/s41598-019-54762-2 |
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This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were <300–532 pmol/L. There were 100 eligible participants with DKD and 92 with DM without DKD. For the identification of participants with DKD, the area under the receiver operating characteristic curve (AUC) for dp-ucMGP was 0.842 (95%CI:0.799–0.880; p < 0.001). Plasma dp-ucMGP demonstrated similar ability to urine albumin:creatinine ratio (uACR) to detect participants with DM and renal function decline. Among patients with DM, there was a negative correlation between natural log (LN) dp-ucMGP and eGFR (r = −0.7041; p < 0.001) and rate of change in renal function [%change (r = −0.4509; p < 0.001)] and a positive correlation between LN dp-ucMGP and LN uACR (r = 0.3392; p < 0.001). These results suggest the potential for plasma dp-ucMGP with well-defined RIs to identify adults at high risk for vascular disease in the context of progressive DKD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-54762-2</identifier><identifier>PMID: 31804541</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45 ; 692/163/2743/137/138 ; 692/308/53/2423 ; 692/4022/1585/104 ; 692/53/2423 ; 82/1 ; 82/56 ; Adolescent ; Adult ; Biomarkers - blood ; Calcium-Binding Proteins - blood ; Creatinine ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - diagnosis ; Diabetic Nephropathies - physiopathology ; Diabetic nephropathy ; Epidermal growth factor receptors ; Extracellular Matrix Proteins - blood ; Female ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Health risk assessment ; Healthy Volunteers ; Humanities and Social Sciences ; Humans ; Kidney diseases ; Kidneys ; Male ; Matrix Gla Protein ; Middle Aged ; multidisciplinary ; Prospective Studies ; Reference Values ; Renal function ; Risk Assessment - methods ; Risk Factors ; ROC Curve ; Science ; Science (multidisciplinary) ; Urine ; Vascular diseases ; White People ; Young Adult</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.18452-13, Article 18452</ispartof><rights>The Author(s) 2019</rights><rights>2019. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ed31f7711ebdc65b6c17657e37a827d39bf5c972f3912fa26039cafc315b9b9d3</citedby><cites>FETCH-LOGICAL-c474t-ed31f7711ebdc65b6c17657e37a827d39bf5c972f3912fa26039cafc315b9b9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31804541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griffin, Tomás Patrick</creatorcontrib><creatorcontrib>Islam, Md Nahidul</creatorcontrib><creatorcontrib>Wall, Deirdre</creatorcontrib><creatorcontrib>Ferguson, John</creatorcontrib><creatorcontrib>Griffin, Damian Gerard</creatorcontrib><creatorcontrib>Griffin, Matthew Dallas</creatorcontrib><creatorcontrib>O’Shea, Paula M.</creatorcontrib><title>Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were <300–532 pmol/L. There were 100 eligible participants with DKD and 92 with DM without DKD. For the identification of participants with DKD, the area under the receiver operating characteristic curve (AUC) for dp-ucMGP was 0.842 (95%CI:0.799–0.880; p < 0.001). Plasma dp-ucMGP demonstrated similar ability to urine albumin:creatinine ratio (uACR) to detect participants with DM and renal function decline. Among patients with DM, there was a negative correlation between natural log (LN) dp-ucMGP and eGFR (r = −0.7041; p < 0.001) and rate of change in renal function [%change (r = −0.4509; p < 0.001)] and a positive correlation between LN dp-ucMGP and LN uACR (r = 0.3392; p < 0.001). These results suggest the potential for plasma dp-ucMGP with well-defined RIs to identify adults at high risk for vascular disease in the context of progressive DKD.</description><subject>631/45</subject><subject>692/163/2743/137/138</subject><subject>692/308/53/2423</subject><subject>692/4022/1585/104</subject><subject>692/53/2423</subject><subject>82/1</subject><subject>82/56</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic nephropathy</subject><subject>Epidermal growth factor receptors</subject><subject>Extracellular Matrix Proteins - blood</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Glomerular Filtration Rate - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griffin, Tomás Patrick</au><au>Islam, Md Nahidul</au><au>Wall, Deirdre</au><au>Ferguson, John</au><au>Griffin, Damian Gerard</au><au>Griffin, Matthew Dallas</au><au>O’Shea, Paula M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-05</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>18452</spage><epage>13</epage><pages>18452-13</pages><artnum>18452</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were <300–532 pmol/L. There were 100 eligible participants with DKD and 92 with DM without DKD. For the identification of participants with DKD, the area under the receiver operating characteristic curve (AUC) for dp-ucMGP was 0.842 (95%CI:0.799–0.880; p < 0.001). Plasma dp-ucMGP demonstrated similar ability to urine albumin:creatinine ratio (uACR) to detect participants with DM and renal function decline. Among patients with DM, there was a negative correlation between natural log (LN) dp-ucMGP and eGFR (r = −0.7041; p < 0.001) and rate of change in renal function [%change (r = −0.4509; p < 0.001)] and a positive correlation between LN dp-ucMGP and LN uACR (r = 0.3392; p < 0.001). These results suggest the potential for plasma dp-ucMGP with well-defined RIs to identify adults at high risk for vascular disease in the context of progressive DKD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31804541</pmid><doi>10.1038/s41598-019-54762-2</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/45 692/163/2743/137/138 692/308/53/2423 692/4022/1585/104 692/53/2423 82/1 82/56 Adolescent Adult Biomarkers - blood Calcium-Binding Proteins - blood Creatinine Cross-Sectional Studies Diabetes Diabetes mellitus Diabetic Nephropathies - blood Diabetic Nephropathies - diagnosis Diabetic Nephropathies - physiopathology Diabetic nephropathy Epidermal growth factor receptors Extracellular Matrix Proteins - blood Female Glomerular filtration rate Glomerular Filtration Rate - physiology Health risk assessment Healthy Volunteers Humanities and Social Sciences Humans Kidney diseases Kidneys Male Matrix Gla Protein Middle Aged multidisciplinary Prospective Studies Reference Values Renal function Risk Assessment - methods Risk Factors ROC Curve Science Science (multidisciplinary) Urine Vascular diseases White People Young Adult |
| title | Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential |
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