Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma
BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma. MATERIAL AND METHODS Surveilla...
Gespeichert in:
| Veröffentlicht in: | Medical science monitor 2019-11, Vol.25, p.8952-8967 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8967 |
|---|---|
| container_issue | |
| container_start_page | 8952 |
| container_title | Medical science monitor |
| container_volume | 25 |
| creator | Gao, Zhongyang Lu, Teng Song, Hui Gao, Zhengchao Ren, Fenggang Ouyang, Pengrong Wang, Yibin Zhu, Junjie Zhou, Songlin He, Xijing |
| description | BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma. MATERIAL AND METHODS Surveillance, Epidemiology, and End Results (SEER) cancer registry database was utilized to extract the chondrosarcoma cases diagnosed between 1973 and 2014. Among these cases, the histological grades of poorly differentiated (grade 3) and undifferentiated (grade 4) were categorized as high-grade and included in this study. Chondrosarcoma OS and CSS were the primary outcomes in the present study. The log-rank test was performed for univariate analysis, and the Cox regression model was conducted for multivariate analysis. RESULTS A total of 743 patients with high-grade chondrosarcoma were identified in this study (430 cases were poorly differentiated tumors, and 313 cases were undifferentiated tumors). Age at diagnosis, pathological grade, histo-type, SEER stage, tumor size and surgical resection were identified as independent predictors in both OS and CSS analysis of high-grade chondrosarcoma. When stratified by histological grade, surgical resection remained the effective treatment. Strikingly, radiotherapy was determined as an independent protective factor in both OS and CSS analysis of undifferentiated (grade 4) dedifferentiated chondrosarcoma, and adjuvant radiotherapy combined surgical resection could improve both the OS and CSS of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma compared with other treatment regimens. CONCLUSIONS Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients' outcome. |
| doi_str_mv | 10.12659/MSM.917959 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6894367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2318732268</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-33344286891d6c53995121d708f5a6ef23b66225e645c97b6ba71ef39d45ef053</originalsourceid><addsrcrecordid>eNpVUcFKAzEQDaLYWj15lxwFWd0km-zmIkixrdDSgvUcstlsN9Ld1CRV_HuDraWeZph5vHlvHgDXKL1HmFH-MHud3XOUc8pPQB-xjCQkp-npUd8DF96_pykuWErPQY-gnFHC8j5YLpxdddYHo-BIqmCdh7Kr4NJpGVrdBTjfBGM7D2vr4EIGE2cefpnQwIlZNcnYyUrDYWO7ylkvnbKtvARntVx7fbWvA_A2el4OJ8l0Pn4ZPk0TRQoUEkJIlkVJBUcVU5RwThFGVZ4WNZVM15iUjGFMNcuo4nnJSpkjXRNeZVTXKSUD8Ljj3WzLVlcqSnNyLTbOtNJ9CyuN-L_pTCNW9lPEk1m0Hwlu9wTOfmy1D6I1Xun1Wnbabr3ABBU5wZgVEXq3g6po0ztdH86gVPzmIGIOYpdDRN8cKztg_x5PfgCnToO3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2318732268</pqid></control><display><type>article</type><title>Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma</title><source>MEDLINE</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Gao, Zhongyang ; Lu, Teng ; Song, Hui ; Gao, Zhengchao ; Ren, Fenggang ; Ouyang, Pengrong ; Wang, Yibin ; Zhu, Junjie ; Zhou, Songlin ; He, Xijing</creator><creatorcontrib>Gao, Zhongyang ; Lu, Teng ; Song, Hui ; Gao, Zhengchao ; Ren, Fenggang ; Ouyang, Pengrong ; Wang, Yibin ; Zhu, Junjie ; Zhou, Songlin ; He, Xijing</creatorcontrib><description>BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma. MATERIAL AND METHODS Surveillance, Epidemiology, and End Results (SEER) cancer registry database was utilized to extract the chondrosarcoma cases diagnosed between 1973 and 2014. Among these cases, the histological grades of poorly differentiated (grade 3) and undifferentiated (grade 4) were categorized as high-grade and included in this study. Chondrosarcoma OS and CSS were the primary outcomes in the present study. The log-rank test was performed for univariate analysis, and the Cox regression model was conducted for multivariate analysis. RESULTS A total of 743 patients with high-grade chondrosarcoma were identified in this study (430 cases were poorly differentiated tumors, and 313 cases were undifferentiated tumors). Age at diagnosis, pathological grade, histo-type, SEER stage, tumor size and surgical resection were identified as independent predictors in both OS and CSS analysis of high-grade chondrosarcoma. When stratified by histological grade, surgical resection remained the effective treatment. Strikingly, radiotherapy was determined as an independent protective factor in both OS and CSS analysis of undifferentiated (grade 4) dedifferentiated chondrosarcoma, and adjuvant radiotherapy combined surgical resection could improve both the OS and CSS of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma compared with other treatment regimens. CONCLUSIONS Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients' outcome.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.917959</identifier><identifier>PMID: 31765367</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Aged ; China ; Chondrosarcoma - classification ; Chondrosarcoma - metabolism ; Chondrosarcoma - surgery ; Chondrosarcoma - therapy ; Clinical Research ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Radiotherapy, Adjuvant - methods ; Registries ; SEER Program ; Survival Analysis ; Treatment Outcome</subject><ispartof>Medical science monitor, 2019-11, Vol.25, p.8952-8967</ispartof><rights>Med Sci Monit, 2019 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-33344286891d6c53995121d708f5a6ef23b66225e645c97b6ba71ef39d45ef053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31765367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Zhongyang</creatorcontrib><creatorcontrib>Lu, Teng</creatorcontrib><creatorcontrib>Song, Hui</creatorcontrib><creatorcontrib>Gao, Zhengchao</creatorcontrib><creatorcontrib>Ren, Fenggang</creatorcontrib><creatorcontrib>Ouyang, Pengrong</creatorcontrib><creatorcontrib>Wang, Yibin</creatorcontrib><creatorcontrib>Zhu, Junjie</creatorcontrib><creatorcontrib>Zhou, Songlin</creatorcontrib><creatorcontrib>He, Xijing</creatorcontrib><title>Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma. MATERIAL AND METHODS Surveillance, Epidemiology, and End Results (SEER) cancer registry database was utilized to extract the chondrosarcoma cases diagnosed between 1973 and 2014. Among these cases, the histological grades of poorly differentiated (grade 3) and undifferentiated (grade 4) were categorized as high-grade and included in this study. Chondrosarcoma OS and CSS were the primary outcomes in the present study. The log-rank test was performed for univariate analysis, and the Cox regression model was conducted for multivariate analysis. RESULTS A total of 743 patients with high-grade chondrosarcoma were identified in this study (430 cases were poorly differentiated tumors, and 313 cases were undifferentiated tumors). Age at diagnosis, pathological grade, histo-type, SEER stage, tumor size and surgical resection were identified as independent predictors in both OS and CSS analysis of high-grade chondrosarcoma. When stratified by histological grade, surgical resection remained the effective treatment. Strikingly, radiotherapy was determined as an independent protective factor in both OS and CSS analysis of undifferentiated (grade 4) dedifferentiated chondrosarcoma, and adjuvant radiotherapy combined surgical resection could improve both the OS and CSS of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma compared with other treatment regimens. CONCLUSIONS Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients' outcome.</description><subject>Adult</subject><subject>Aged</subject><subject>China</subject><subject>Chondrosarcoma - classification</subject><subject>Chondrosarcoma - metabolism</subject><subject>Chondrosarcoma - surgery</subject><subject>Chondrosarcoma - therapy</subject><subject>Clinical Research</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant - methods</subject><subject>Registries</subject><subject>SEER Program</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcFKAzEQDaLYWj15lxwFWd0km-zmIkixrdDSgvUcstlsN9Ld1CRV_HuDraWeZph5vHlvHgDXKL1HmFH-MHud3XOUc8pPQB-xjCQkp-npUd8DF96_pykuWErPQY-gnFHC8j5YLpxdddYHo-BIqmCdh7Kr4NJpGVrdBTjfBGM7D2vr4EIGE2cefpnQwIlZNcnYyUrDYWO7ylkvnbKtvARntVx7fbWvA_A2el4OJ8l0Pn4ZPk0TRQoUEkJIlkVJBUcVU5RwThFGVZ4WNZVM15iUjGFMNcuo4nnJSpkjXRNeZVTXKSUD8Ljj3WzLVlcqSnNyLTbOtNJ9CyuN-L_pTCNW9lPEk1m0Hwlu9wTOfmy1D6I1Xun1Wnbabr3ABBU5wZgVEXq3g6po0ztdH86gVPzmIGIOYpdDRN8cKztg_x5PfgCnToO3</recordid><startdate>20191125</startdate><enddate>20191125</enddate><creator>Gao, Zhongyang</creator><creator>Lu, Teng</creator><creator>Song, Hui</creator><creator>Gao, Zhengchao</creator><creator>Ren, Fenggang</creator><creator>Ouyang, Pengrong</creator><creator>Wang, Yibin</creator><creator>Zhu, Junjie</creator><creator>Zhou, Songlin</creator><creator>He, Xijing</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191125</creationdate><title>Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma</title><author>Gao, Zhongyang ; Lu, Teng ; Song, Hui ; Gao, Zhengchao ; Ren, Fenggang ; Ouyang, Pengrong ; Wang, Yibin ; Zhu, Junjie ; Zhou, Songlin ; He, Xijing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-33344286891d6c53995121d708f5a6ef23b66225e645c97b6ba71ef39d45ef053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>China</topic><topic>Chondrosarcoma - classification</topic><topic>Chondrosarcoma - metabolism</topic><topic>Chondrosarcoma - surgery</topic><topic>Chondrosarcoma - therapy</topic><topic>Clinical Research</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant - methods</topic><topic>Registries</topic><topic>SEER Program</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Gao, Zhongyang</creatorcontrib><creatorcontrib>Lu, Teng</creatorcontrib><creatorcontrib>Song, Hui</creatorcontrib><creatorcontrib>Gao, Zhengchao</creatorcontrib><creatorcontrib>Ren, Fenggang</creatorcontrib><creatorcontrib>Ouyang, Pengrong</creatorcontrib><creatorcontrib>Wang, Yibin</creatorcontrib><creatorcontrib>Zhu, Junjie</creatorcontrib><creatorcontrib>Zhou, Songlin</creatorcontrib><creatorcontrib>He, Xijing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Zhongyang</au><au>Lu, Teng</au><au>Song, Hui</au><au>Gao, Zhengchao</au><au>Ren, Fenggang</au><au>Ouyang, Pengrong</au><au>Wang, Yibin</au><au>Zhu, Junjie</au><au>Zhou, Songlin</au><au>He, Xijing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2019-11-25</date><risdate>2019</risdate><volume>25</volume><spage>8952</spage><epage>8967</epage><pages>8952-8967</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma. MATERIAL AND METHODS Surveillance, Epidemiology, and End Results (SEER) cancer registry database was utilized to extract the chondrosarcoma cases diagnosed between 1973 and 2014. Among these cases, the histological grades of poorly differentiated (grade 3) and undifferentiated (grade 4) were categorized as high-grade and included in this study. Chondrosarcoma OS and CSS were the primary outcomes in the present study. The log-rank test was performed for univariate analysis, and the Cox regression model was conducted for multivariate analysis. RESULTS A total of 743 patients with high-grade chondrosarcoma were identified in this study (430 cases were poorly differentiated tumors, and 313 cases were undifferentiated tumors). Age at diagnosis, pathological grade, histo-type, SEER stage, tumor size and surgical resection were identified as independent predictors in both OS and CSS analysis of high-grade chondrosarcoma. When stratified by histological grade, surgical resection remained the effective treatment. Strikingly, radiotherapy was determined as an independent protective factor in both OS and CSS analysis of undifferentiated (grade 4) dedifferentiated chondrosarcoma, and adjuvant radiotherapy combined surgical resection could improve both the OS and CSS of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma compared with other treatment regimens. CONCLUSIONS Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients' outcome.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>31765367</pmid><doi>10.12659/MSM.917959</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1643-3750 |
| ispartof | Medical science monitor, 2019-11, Vol.25, p.8952-8967 |
| issn | 1643-3750 1234-1010 1643-3750 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6894367 |
| source | MEDLINE; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adult Aged China Chondrosarcoma - classification Chondrosarcoma - metabolism Chondrosarcoma - surgery Chondrosarcoma - therapy Clinical Research Female Humans Male Middle Aged Multivariate Analysis Prognosis Radiotherapy, Adjuvant - methods Registries SEER Program Survival Analysis Treatment Outcome |
| title | Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A01%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Factors%20and%20Treatment%20Options%20for%20Patients%20with%20High-Grade%20Chondrosarcoma&rft.jtitle=Medical%20science%20monitor&rft.au=Gao,%20Zhongyang&rft.date=2019-11-25&rft.volume=25&rft.spage=8952&rft.epage=8967&rft.pages=8952-8967&rft.issn=1643-3750&rft.eissn=1643-3750&rft_id=info:doi/10.12659/MSM.917959&rft_dat=%3Cproquest_pubme%3E2318732268%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2318732268&rft_id=info:pmid/31765367&rfr_iscdi=true |